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Targeting RNA and Protein Turnover in Aneuploid Cancers
Cancer Discovery ( IF 29.7 ) Pub Date : 2024-12-02 , DOI: 10.1158/2159-8290.cd-24-1350
Samuel F. Bakhoum

Summary:Aneuploidy, an imbalance in chromosome number, is a hallmark of human cancers with chromosomal instability, and it remains a major therapeutic challenge. In this issue, Ippolito and colleagues identify RNA and protein turnover as targetable therapeutic vulnerabilities in aneuploid cancers.See related article by Ippolito et al., p. 2532

中文翻译:


在无倍体癌症中靶向 RNA 和蛋白质周转



摘要: 非整倍体是一种染色体数量的不平衡,是染色体不稳定的人类癌症的标志,它仍然是一个主要的治疗挑战。在本期中,Ippolito 及其同事将 RNA 和蛋白质周转确定为非整倍体癌症中可靶向的治疗脆弱性。参见 Ippolito 等人的相关文章,第 2532 页
更新日期:2024-12-02
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