Summary:The study by Grossmann and colleagues uses single-nucleus RNA sequencing in a cohort of matched high-risk neuroblastoma primary tumor samples, obtained from the same patient at diagnosis and definitive surgery, to identify persister cells that survive induction chemotherapy. These persister cells utilize mechanisms of chemoresistance that are both tumor-intrinsic and tumor-extrinsic, are highly dependent on the original genetic profile of the tumor, and represent novel, patient-specific targets to precisely inhibit chemoresistance and disease recurrence.See related article by Grossmann et.al., p. 2387

中文翻译：

---

持久性细胞的表征为神经母细胞瘤治疗耐药机制提供了见解


摘要： Grossmann 及其同事的研究在一组匹配的高危神经母细胞瘤原发性肿瘤样本中使用单核 RNA 测序，这些样本在诊断和确定性手术时从同一患者获得，以鉴定在诱导化疗中存活的持久性细胞。这些持久性细胞利用肿瘤内源性和肿瘤外源性的化疗耐药机制，高度依赖于肿瘤的原始遗传谱，并代表了新的、患者特异性的靶点，以精确抑制化疗耐药和疾病复发。参见 Grossmann et.al. 的相关文章，第 2387 页