Proteolytic chimeras constructed from various bioactive modules can degrade either cytoplasmic or extracellular proteins, but their pharmacology faces challenges. Now, a protein degradation platform built with engineered platelets enables the targeted depletion of intracellular and extracellular proteins at hemorrhagic sites, addressing several limitations associated with proteolytic chimeras.

中文翻译：

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蛋白水解血小板作为靶向蛋白质降解剂


由各种生物活性模块构建的蛋白水解嵌合体可以降解细胞质或细胞外蛋白，但它们的药理学面临挑战。现在，使用工程化血小板构建的蛋白质降解平台能够在出血部位靶向耗竭细胞内和细胞外蛋白质，解决了与蛋白水解嵌合体相关的几个限制。