Nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase (COX)-2-specific inhibitors provide significant analgesic and opioid-sparing benefits. However, these analgesics are commonly avoided owing to concerns of potential adverse effects. The evidence for NSAID-related adverse effects is conflicting and of poor quality, and these analgesics are safer than what has been implied. Thus, it is imperative that NSAIDs or COX-2-specific inhibitors are administered routinely unless there are well-founded contraindications.

中文翻译：

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围手术期非甾体类抗炎药：目前的争议和担忧。


非甾体抗炎药 （NSAIDs） 和环氧合酶 （COX）-2 特异性抑制剂具有显著的镇痛和阿片类药物节用益处。然而，由于担心潜在的不良反应，通常避免使用这些镇痛药。NSAID 相关不良反应的证据相互矛盾且质量差，这些镇痛药比暗示的更安全。因此，除非有充分的禁忌证，否则必须常规使用 NSAID 或 COX-2 特异性抑制剂。