We would like to thank Dunne et al 1 for their interest in our work.2 Their main concerns are that the rates of liver-related events (LREs) including progression to ascites were similar in both the groups in spite of lower mortality and oesophageal variceal bleed (OVB) in the combination arm as compared with the other arms. Second, the rates of OVBs and the bleed-related mortality were higher in the carvedilol arm as compared with the other arms. We would like to emphasise that in our study, we did not find any significant difference between the carvedilol arm and the combination arm in the reduction of hepatic venous pressure gradient (HVPG). The latter has been shown to correlate with various LREs and their progression.3 The reduction by 10% or …

中文翻译：

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高危食管静脉曲张患者的一级预防以预防食管静脉曲张出血 （OVB）——CAVARLY 一起更强大！！


我们要感谢 Dunne 等人 1 对我们工作的关注.2 他们主要担心的是，尽管与其他组相比，联合组的死亡率和食管静脉曲张出血 （OVB） 较低，但两组的肝脏相关事件 （RRE） 发生率相似，包括进展为腹水。其次，与其他组相比，卡维地洛组的 OVBs 发生率和出血相关死亡率更高。我们想强调的是，在我们的研究中，我们没有发现卡维地洛组和联合治疗组在降低肝静脉压力梯度 （HVPG） 方面有任何显著差异。后者已被证明与各种 LRE 及其进展相关.3 减少 10% 或......