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Next-Generation Sequencing for HLA Genotype Screening and Matching to HLA-Restricted Therapies
JAMA Oncology ( IF 22.5 ) Pub Date : 2024-11-27 , DOI: 10.1001/jamaoncol.2024.5364
Michael V. Gormally, Monica F. Chen, Anne Marie Noronha, Kristalla Panageas, Maggie Reynolds, Kaelyn Kohlasch, Bryan Novak, Tatiana Kee-Velez, Nikeysha Clarke, Michael Eubank, Cynthia Chu, Clare Wilhelm, Amanda Blouin, Chrisann Kyi, Claire Friedman, Charles M. Rudin, Mark G. Kris, Ronak Shah, David Aggen, Sandra D’Angelo, Alexander N. Shoushtari, Michael F. Berger, Chaitanya Bandlamudi, Christopher A. Klebanoff, Alexander Drilon, Adam J. Schoenfeld, Mark T. A. Donoghue

This case series evaluates whether human leukocyte antigen (HLA) genotype could be inferred from standard next-generation sequencing, comparing concordance with confirmatory whole-exome sequencing and assessing if this assisted in matching patients to clinical trials.

中文翻译:


用于 HLA 基因型筛查和与 HLA 限制性疗法匹配的下一代测序



本病例系列评估是否可以从标准的下一代测序中推断出人类白细胞抗原 (HLA) 基因型,将一致性与验证性全外显子组测序进行比较,并评估这是否有助于将患者与临床试验相匹配。
更新日期:2024-11-27
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