Late-life air pollution exposure is associated with an increased risk for dementia, with this effect exacerbated among apolipoprotein E-4 (ApoE-4) carriers. However, whether midlife occupational exposures likewise influence dementia outcomes, and varies as a function of ApoE-4 status is unknown.

中文翻译：

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威斯康星州纵向研究中中年和晚年环境暴露对痴呆风险的影响：ApoE 的修饰作用


晚年空气污染暴露与痴呆风险增加有关，这种影响在载脂蛋白 E-4 （ApoE-4） 携带者中加剧。然而，中年职业暴露是否同样影响痴呆结果，并且随着 ApoE-4 状态的变化而变化尚不清楚。