Approximately 35% of long-term cancer survivors experience ongoing cancer-related cognitive impairment (CRCI). Yet, few efficacious interventions exist to prevent or ameliorate CRCI. The underlying biological processes driving CRCI are complex and are reported to include changes in brain structure and function, increased oxidative stress and inflammation, and alterations in gut microbiome composition. Some of the mechanisms promoting CRCI have the potential to be modified through behavioral changes, such as dietary changes. Compelling evidence from randomized controlled trials and observational research supports the positive impacts of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on cognition outside of the context of cancer, but studies investigating the MIND diet as an intervention for people who experience CRCI are lacking. This review examines the current state of the science for cognitive outcomes of dietary interventions in aging populations and discusses future opportunities to adapt these interventions to cancer populations.

中文翻译：

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癌症相关认知障碍以及饮食干预预防和缓解神经退行性变的潜力


大约 35% 的长期癌症幸存者会经历持续的癌症相关认知障碍 （CRCI）。然而，很少有有效的干预措施可以预防或改善 CRCI。驱动 CRCI 的潜在生物过程很复杂，据报道包括大脑结构和功能的变化、氧化应激和炎症的增加以及肠道微生物组组成的改变。一些促进 CRCI 的机制有可能通过行为改变（例如饮食改变）来改变。来自随机对照试验和观察性研究的令人信服的证据支持地中海-DASH 神经退行性延迟干预 （MIND） 饮食对癌症背景外认知的积极影响，但缺乏调查 MIND 饮食作为 CRCI 患者干预措施的研究。本综述研究了老龄化人群饮食干预认知结果的科学现状，并讨论了使这些干预措施适应癌症人群的未来机会。