Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent issue of Nature, Osterman et al.¹ reveal two phage-encoded NAD restoration pathways, showcasing the phages’ innovative counterstrategies against bacterial immunity and providing insights for developing novel antimicrobial approaches.

中文翻译：

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NAD 重装上阵：破解细菌防御


烟酰胺腺嘌呤二核苷酸 （NAD） 是一种必需的代谢物，其耗竭是针对噬菌体（噬菌体）的常见细菌免疫策略。在最近一期的《自然》杂志上，Osterman 等人¹ 揭示了两种噬菌体编码的 NAD 恢复途径，展示了噬菌体对细菌免疫的创新对抗策略，并为开发新的抗菌方法提供了见解。