INTRODUCTIONPatterns of signal from tau positron emission tomography (tau‐PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer's disease (AD) research if they are linked to differential biomarker levels and cognitive decline.METHODSVisual assessment of Tau‐PET [F‐18]florquinitau (FQT) exams from 728 initially non‐demented older adults yielded four uptake groups: tau‐negative (T−), MTL‐only (T+MTL), neocortex‐only (T+Neo), or both (T+MTL&Neo). Mixed effects models assessed group differences in retrospective cognitive and plasma pTau217 trajectories.RESULTST+MTL&Neo was the most common T+ group (n = 97; 93% A+) and exhibited the sharpest worsening in cognitive and pTau217 trajectories before tau PET.DISCUSSIONThe T+MTL&Neo category represents an intermediate to advanced stage of AD preceded by rising ptau217 and progressive cognitive decline. The pTau217 finding suggests that A+, T+ in MTL or neocortex could represent early AD stages, with a higher likelihood of progressing to more advanced stages.Highlights Visual assessments of Tau‐PET FQT revealed four distinct uptake groups: tau‐negative (T−), MTL‐only (T+MTL), neocortex‐only (T+Neo), or both (T+MTL&Neo). Amyloid positive participants in the T+MTL and T+MTL&Neo categories showed a retrospectively faster decline in their cognitive trajectories, and a sharper increase in pTau217 levels in plasma, compared to T−. The T+MTL&Neo group displayed sharper trajectories compared with the other Tau positive groups in both their cognitive scores and pTau217 plasma levels. Our results suggest that participants with Tau present in both MTL and neocortex represent an intermediate to advanced stage of AD, whereas participants with signals confined to either MTL or neocortex could represent earlier AD stages.

中文翻译：

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[F-18]florquinitau PET 的视觉读取包括并延伸到近中颞叶之外，与血浆 pTau217 增加和认知能力下降有关，该队列富含阿尔茨海默病的风险


引言 局限于内侧颞叶 （MTL） 或延伸到新皮层的 tau 正电子发射断层扫描 （tau-PET） 信号的信号可能与阿尔茨海默病 （AD） 研究相关，如果它们与不同的生物标志物水平和认知能力下降有关。方法对 728 名最初非痴呆老年人的 Tau-PET [F-18]florquinitau （FQT） 检查进行自然评估，得出四个摄取组：tau 阴性 （T-）、仅 MTL （T+MTL）、仅新皮层 （T+Neo） 或两者兼而有之 （T+MTL&Neo）。混合效应模型评估了回顾性认知和血浆 pTau217 轨迹的组别差异。结果T+MTL&Neo 是最常见的 T+ 组 （n = 97;93% A+），并且在 tau PET 之前认知和 pTau217 轨迹表现出最急剧的恶化。讨论T+MTL&Neo 类别代表 AD 的中晚期，之前是 ptau217 升高和进行性认知能力下降。pTau217 研究结果表明，MTL 或新皮层中的 A+、T+ 可能代表早期 AD 阶段，更有可能发展到更晚期。亮点 Tau-PET FQT 的视觉评估揭示了四个不同的摄取组：tau 阴性 （T-）、仅 MTL （T+MTL）、仅新皮层 （T+Neo） 或两者兼而有之 （T+MTL&Neo）。与 T− 相比，T+MTL 和 T+MTL&Neo 类别中的淀粉样蛋白阳性参与者的认知轨迹回顾性下降更快，血浆中 pTau217 水平增加更急剧。与其他 Tau 阳性组相比，T+MTL&Neo 组在认知评分和 pTau217 血浆水平方面均表现出更清晰的轨迹。 我们的结果表明，MTL 和新皮层中同时存在 Tau 的参与者代表 AD 的中晚期，而信号局限于 MTL 或新皮层的参与者可能代表早期 AD 阶段。