Section snippets

Associations of Self-Reported Race, Social Determinants of Health, and Polygenic Risk With Coronary Heart Disease

2157Kristjan Norland, Daniel J. Schaid, Mohammadreza Naderian, Jie Na, Iftikhar J. KulloIn a study of 67,256 All of Us participants, the authors tested the associations of self-reported race/ethnicity, social determinants of health (SDOH), and polygenic risk with coronary heart disease (CHD). The authors ascertained self-reported race/ethnicity, created an SDOH score for CHD (SDOH_CHD) derived from 22 SDOH measures, and computed a polygenic risk score for CHD (PRS_CHD). SDOH_CHD was highest in

Consequences of Discontinuing Long-Term Drug Treatment in Patients With Heart Failure and Reduced Ejection Fraction

2215Khawaja M. Talha, Javed Butler, Milton PackerThe withdrawal of long-term treatment can follow 1 of 4 patterns: 1) loss of on-treatment effect with no changes following discontinuation (eg, prazosin); 2) attenuation or loss of on-treatment effect with rebound worsening following discontinuation (eg, nitroprusside); 3) persistence of deleterious on-treatment effect followed by worsening after discontinuation (eg, milrinone and flosequinan); and 4) persistence of favorable on-treatment effect

Why Have We Not Been Able to Demonstrate Reduced Mortality in Patients With HFmrEF/HFpEF?

2233Toru Kondo, Alasdair D. Henderson, Kieran F. Docherty, Pardeep S. Jhund, Muthiah Vaduganathan, Scott D. Solomon, John J.V. McMurray

Why Has it Been Challenging to Modify Kidney Disease Progression in Patients With Heart Failure?

2241Muthiah Vaduganathan, Brendon L. Neuen, Finnian McCausland, Pardeep S. Jhund, Kieran F. Docherty, John J.V. McMurray, Scott D. Solomon

Bidirectional Relationship Between Kidney Disease Progression and Cardiovascular Events in Type 2 Diabetes

2246Brendon L. Neuen, John W. Ostrominski, Brian Claggett, Iris E. Beldhuis, Safia Chatur, Finnian R. McCausland, Sunil V. Badve, Clare Arnott, Hiddo J.L. Heerspink, Min Jun, Michael Falster, Juliana de Oliveira Costa, Carol Pollock, Meg J. Jardine, Kenneth W. Mahaffey, Vlado Perkovic, Scott D. Solomon, Muthiah Vaduganathan

ONLINE LETTER TO THE EDITOR Answering the Call: Enhancing Telemedicine Reach With Artificial intelligence Integration

e311Ioannis Skalidis, Niccolo Maurizi, George Dangas, Yiannis S. Chatzizisis

ONLINE LETTER TO THE EDITOR Reply

Adam Hartley, Nasser Alshahrani, Ramzi Y. Khamis

ONLINE LETTER TO THE EDITOR Revealing the Hidden Layers: Focus on Social and Psychological Determinants in Congenital Heart Surgery Prognosis

e315Zhangxin Wen, Sihan Duan, Hong Liu

ONLINE LETTER TO THE EDITOR Reply

Sarah Crook, Brett R. Anderson, The New York State Congenital Heart Surgery Collaborative for Longitudinal Outcomes and Utilization of Resources (CHS-COLOUR)

ONLINE LETTER TO THE EDITOR Glycemic Control and Coronary Stent Failure in Patients With Type 2 Diabetes Mellitus

e319Chao Liu, Ximing Li, Hongliang Cong

ONLINE LETTER TO THE EDITOR Reply

Irene Santos-Pardo, Mikael Andersson Franko, Thomas Nyström

ONLINE LETTER TO THE EDITOR Clinical Signs of Congestion in Younger Patients With Decompensated Heart Failure

e323Jaimie Coburn, Pieter A. Neef, Simon Hobson, Jonathan R. DalzellTHESE ARTICLES

中文翻译：

---

 内容

 部分片段

自我报告的种族、健康的社会决定因素和多基因风险与冠心病的关联

2157 元Kristjan Norland、Daniel J. Schaid、Mohammadreza Naderian、Jie Na、Iftikhar J. Kullo在一项对 67,256 名我们所有人参与者的研究中，作者测试了自我报告的种族/民族、健康的社会决定因素 （SDOH） 和多基因风险与冠心病 （CHD） 的关联。作者确定了自我报告的种族/民族，创建了从 22 个 SDOH 测量得出的 CHD SDOH 评分 （SDOH_CHD），并计算了 CHD 的多基因风险评分 （PRS_CHD）。SDOH_CHD 最高

射血分数降低的心力衰竭患者停止长期药物治疗的后果

2215 元Khawaja M. Talha， Javed Butler， Milton Packer停止长期治疗可以遵循以下 4 种模式之一： 1） 停药后治疗效果丧失且无变化（例如，哌唑嗪）;2） 停药后治疗效果减弱或丧失，反弹恶化（例如，硝普钠）;3） 有害治疗效果的持续存在，停药后恶化（例如，米力农和氟西奎诺）;4） 良好的治疗效果持续

为什么我们无法证明 HFmrEF/HFpEF 患者的死亡率降低？

2233 元Toru Kondo， Alasdair D. Henderson， Kieran F. Docherty， Pardeep S. Jhund， Muthiah Vaduganathan， Scott D. Solomon， John J.V. McMurray

为什么改变心力衰竭患者的肾脏疾病进展具有挑战性？

2241 元Muthiah Vaduganathan、Brendon L. Neuen、Finnian McCausland、Pardeep S. Jhund、Kieran F. Docherty、John J.V. McMurray、Scott D. Solomon

2 型糖尿病肾病进展与心血管事件之间的双向关系

2246 元Brendon L. Neuen， John W. Ostrominski， Brian Claggett， Iris E. Beldhuis， Safia Chatur， Finnian R. McCausland， Sunil V. Badve， Clare Arnott， Hiddo J.L. Heerspink， Min Jun， Michael Falster， Juliana de Oliveira Costa， Carol Pollock， Meg J. Jardine， Kenneth W. Mahaffey， Vlado Perkovic， Scott D. Solomon， Muthiah Vaduganathan

给编辑的在线信响应号召：通过人工智能集成增强远程医疗覆盖面

编号 E311扬尼斯·斯卡利迪斯、尼科洛·毛里齐、乔治·丹加斯、扬尼斯·查齐齐西斯

给编辑的在线信 回复

亚当·哈特利、纳赛尔·阿尔沙赫拉尼、拉姆齐·哈米斯

给编辑的在线信揭示隐藏的层次：关注先天性心脏手术预后的社会和心理决定因素

编号 E315温章欣， 段思涵， 刘宏

给编辑的在线信 回复

Sarah Crook、Brett R. Anderson，纽约州先天性心脏手术纵向结果和资源利用合作组织 （CHS-COLOUR）

给编辑的在线信 2 型糖尿病患者的血糖控制和冠状动脉支架衰竭

编号 E319刘超， 李希明， 丛洪亮

给编辑的在线信 回复

艾琳·桑托斯-帕尔多、米凯尔·安德森·弗兰科、托马斯·尼斯特伦

给编辑的在线信 年轻失代偿性心力衰竭患者充血的临床体征

编号 E323Jaimie Coburn、Pieter A. Neef、Simon Hobson、Jonathan R. Dalzell这些文章