OBJECTIVE Evidence for an association of smoking with gout is conflicting. We assessed associations of current and past smoking with gout in an Aotearoa New Zealand (NZ) population. METHODS Multivariable logistic regression analysis was performed on cross-sectional data from participants of NZ Māori (from 2 studies: Genetics of Gout in Aotearoa [GGA] study of 293 participants with gout and 431 without; and Ngāti Porou Hauora [NPH] study of 111 participants with gout and 42 without), Pacific people (257 participants with gout and 357 without), and European (694 participants with gout and 688 without) ancestry. RESULTS Current smoking was not associated with gout in NZ Māori (GGA: adjusted odds ratio [aOR] 1.54, P = 0.13; NPH: aOR 3.02, P = 0.10), Pacific people (aOR 0.64, P = 0.21), or European (aOR 0.92, P = 0.80) cohorts. Ex-smoker status was associated with higher gout prevalence in Māori cohorts (GGA: aOR 1.71, P = 0.02; NPH: aOR 7.95, P < 0.001), but not in Pacific people (aOR 1.10, P = 0.69) or European (aOR 1.18, P = 0.22) cohorts. Associations were independent of age, sex, BMI, alcohol intake, kidney function, hypertension, diabetes, physical activity, sugary drink consumption, education, and employment. No association of smoker status with serum urate concentrations was observed in participants without gout. CONCLUSION Ex-smoker status was associated with higher gout prevalence in people of NZ Māori ancestry. No association of current smoking with gout was observed across ancestral groups, raising uncertainties about the relevance of an association specific to ex-smokers.

中文翻译：

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新西兰 Aotearoa 毛利人过去吸烟状况与痛风的关联。


目的 吸烟与痛风相关的证据是相互矛盾的。我们评估了新西兰 （NZ） Aotearoa 人群当前和过去吸烟与痛风的关联。方法 对新西兰毛利人参与者的横断面数据进行多变量 logistic 回归分析（来自 2 项研究：293 名痛风患者和 431 名非痛风参与者的 Aotearoa 痛风遗传学 [GGA] 研究;和 Ngāti Porou Hauora [NPH] 研究，111 名痛风患者和 42 名无痛风参与者）、太平洋人群（257 名痛风患者和 357 名无痛风参与者）， 和欧洲 （694 名患有痛风的参与者和 688 名没有痛风的参与者） 血统。结果 新西兰毛利人当前吸烟与痛风无关 （GGA：调整比值比 [aOR] 1.54，P = 0.13;NPH：aOR 3.02，P = 0.10）、太平洋人群 （aOR 0.64，P = 0.21） 或欧洲人 （aOR 0.92，P = 0.80） 队列。在毛利队列中，戒烟者身份与较高的痛风患病率相关 （GGA： aOR 1.71，P = 0.02;NPH：aOR 7.95，P < 0.001），但在太平洋人群 （aOR 1.10，P = 0.69） 或欧洲人群 （aOR 1.18，P = 0.22） 队列中未见。关联与年龄、性别、BMI、酒精摄入量、肾功能、高血压、糖尿病、身体活动、含糖饮料消费、教育和就业无关。在没有痛风的参与者中未观察到吸烟者状态与血清尿酸盐浓度的关联。结论 戒烟者身份与新西兰毛利血统人群较高的痛风患病率相关。在祖先群体中没有观察到当前吸烟与痛风的关联，这增加了前吸烟者特有关联相关性的不确定性。