STUDY OBJECTIVE Overdue cervical cancer screening increases the risk of invasive cervical cancer. It is important to identify settings where self-collection for primary human papillomavirus (HPV) testing can be implemented to have high effect on cervical cancer screening among hard-to-reach women with overdue screening. Herein, we examined the acceptability of HPV self-collection, including completion rates, attitudes, and experiences among women seeking noncritical care at a high-volume urban safety-net hospital emergency department (ED) in Houston, Texas, United States. METHODS In this single-arm intervention pilot study, we recruited women overdue for cervical cancer screening in the waiting areas of a safety-net hospital ED, seeking noncritical care from November 2023 to April 2024. Participants completed a preintervention survey and were offered an HPV self-collection kit. A postintervention survey followed immediately after HPV self-collection. RESULTS Nearly 30% (119 of 401) screened for eligibility were overdue for cervical cancer screening. Of these, 93% were enrolled and were predominantly Hispanic, non-US born, and uninsured, with a median age of 45 years (IQR: 37 to 53). HPV self-collection completion rate was 90% (95% CI 82.9% to 94.9%). More than a quarter (27%) of these women had never been screened, and 14% had a screening >10 years prior. Most women who completed the HPV self-collection had positive attitudes and experiences and reported that the kit was easy to use (97%) and would be very willing to use HPV self-collection for regular screening (88%). CONCLUSION HPV self-collection for primary cervical cancer screening during noncritical ED visits is possible and highly acceptable among women overdue for cervical cancer screening.

中文翻译：

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用于初级 HPV 检测的自我采集：在大型城市急诊科的可接受性。


研究目的 逾期宫颈癌筛查会增加浸润性宫颈癌的风险。重要的是要确定可以实施原发性人瘤病毒 （HPV） 检测的自我采集对难以到达的逾期筛查妇女的宫颈癌筛查产生重要影响。在此，我们检查了 HPV 自我采集的可接受性，包括在美国德克萨斯州休斯顿的高容量城市安全网医院急诊科 （ED） 寻求非重症护理的女性的完成率、态度和经验。方法 在这项单臂干预试点研究中，我们招募了 2023 年 11 月至 2024 年 4 月期间在安全网医院急诊室的等候区接受宫颈癌筛查的妇女，寻求非重症监护。参与者完成了干预前调查，并获得了 HPV 自我采集试剂盒。在 HPV 自我采集后立即进行干预后调查。结果 近 30% （401 例中的 119 例） 的资格筛查逾期未进行宫颈癌筛查。其中，93% 被纳入，主要是西班牙裔、非美国出生和没有保险，中位年龄为 45 岁 （IQR： 37 至 53）。HPV 自我采集完成率为 90% （95% CI 82.9%， 94.9%）。这些女性中超过四分之一 （27%） 从未接受过筛查，14% 的女性在 >10 年前接受过筛查。大多数完成 HPV 自我采集的女性都有积极的态度和经历，并报告说该试剂盒易于使用 （97%），并且非常愿意使用 HPV 自我采集进行定期筛查 （88%）。结论 在非危重 ED 就诊期间，在非危重 ED 就诊期间进行 HPV 自我采集用于原发性宫颈癌筛查是可能的，并且在逾期接受宫颈癌筛查的女性中具有高度可接受性。