OBJECTIVE To assess the frequency of hepatitis C virus (HCV) testing among a population-based cohort of perinatally exposed children and identify factors associated with testing. METHODS Using a population-based surveillance cohort of perinatally exposed children born from 2018 to 2020 from 4 US jurisdictions (Georgia; Massachusetts; Allegheny County, Pennsylvania; and Los Angeles County, California), we describe the frequency, timing, and type of HCV testing among children and identify characteristics associated with having an HCV test result by the age of 2 to 3 years. Data were obtained from electronic laboratory reporting, vital records, and medical records. RESULTS Of 803 perinatally exposed children, 7 (1%) died before the age of 24 months. Of 796 children, health departments were unable to find medical records or laboratory reports for 181 (23%). Among those with medical record abstraction at 24 months or testing reported before the age of 3 years (n = 615), 50% had an HCV test. The majority (70% of those tested) were tested for HCV antibodies at the age of 18 months or later, although 9% had an HCV nucleic acid test at ages 2 to <6 months. No characteristics examined were found to be significantly associated with having testing reported. CONCLUSIONS In this surveillance report, we identify the gaps in current testing among children perinatally exposed to hepatitis C. Provider education and resources for health departments for follow-up and linkage to care can improve the identification of children requiring treatment, a vital piece of HCV elimination.

中文翻译：

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围产期暴露儿童的丙型肝炎病毒检测：2018 年至 2020 年。


目的 评估围产期暴露儿童人群中丙型肝炎病毒 （HCV） 检测的频率，并确定与检测相关的因素。方法 使用来自美国 4 个司法管辖区（佐治亚州;麻萨诸塞州;宾夕法尼亚州阿勒格尼县;和加利福尼亚州洛杉矶县）的研究中，我们描述了儿童 HCV 检测的频率、时间和类型，并确定了与 2 至 3 岁时获得 HCV 检测结果相关的特征。数据来自电子实验室报告、生命记录和医疗记录。结果 在 803 例围产期暴露儿童中，7 例 （1%） 在 24 个月前死亡。在 796 名儿童中，卫生部门无法找到 181 名 （23%） 的医疗记录或实验室报告。在 24 个月时提取病历或在 3 岁之前报告检测 （n = 615） 的患者中，50% 进行了 HCV 检测。大多数 （70% 的受测者） 在 18 个月或更晚时接受了 HCV 抗体检测，尽管 9% 的患者在 2 至 <6 个月大时进行了 HCV 核酸检测。未发现所检查的特征与报告检测显著相关。结论 在本监测报告中，我们确定了围产期暴露于丙型肝炎的儿童当前检测的差距。为卫生部门提供随访和护理联系的教育和资源可以改善对需要治疗的儿童的识别，这是消除 HCV 的重要组成部分。