BACKGROUND In the absence of outcome-based ambulatory blood pressure (BP) data hypertension guidelines provide 24-hour mean BP values corresponding to trial-validated office BP values. Data are shown for untreated and treated patients together, but whether corresponding ambulatory values are similar in untreated and treated hypertensives and reproducible at yearly measurements during treatment is undefined. METHODS In 2397 patients of the ELSA (European Lacidipine Study on Atherosclerosis) and PHYLLIS (Plaque Hypertension Lipid-Lowering Italian Study) trials, we calculated the office and 24-hour BP relationship according to the linear regression model, with office systolic BP as the independent variable, at baseline and yearly during a 3-year treatment. Twenty-four hour BP values corresponding to clinically important office BP values (hypertension grades and treatment thresholds and targets) were calculated and compared with those provided by guidelines. RESULTS Office/24-hour systolic BP or diastolic BP always exhibited a significant linear relationship, with, however, limited Pearson correlation coefficients (never >0.44).The slopes of the relationship were superimposable between different years of treatment but always significantly less steep than the slope seen in untreated individuals. Compared with the guideline-provided corresponding values, 24-hour BP showed qualitative and quantitative differences; for example, it was considerably lower and higher than the guideline-corresponding values when office BP was in the high hypertension and low treatment target ranges, respectively. CONCLUSIONS In treated patients with hypertension the slope of the office/24-hour BP linear regression is reproducible over time. However, the slopes are steeper in untreated individuals, indicating that information on ambulatory BP values corresponding to office BP values can be more accurate if separately estimated in these 2 conditions.

中文翻译：

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诊室和动态压力关系的可重复性和治疗效果。


背景：在缺乏基于结果的动态血压 （BP） 数据的情况下，高血压指南提供了与试验验证的诊室血压值相对应的 24 小时平均血压值。未治疗和治疗患者的数据一起显示，但未治疗和治疗高血压患者的相应动态值是否相似，并且在治疗期间的年度测量中是否可重现尚不确定。方法 在 ELSA（欧洲动脉粥样硬化拉西地平研究）和 PHYLLIS （斑块状高血压降脂意大利研究）试验的 2397 名患者中，我们根据线性回归模型计算诊室和 24 小时血压的关系，以诊室收缩压为自变量，在基线和 3 年治疗期间每年。计算与临床上重要的诊室血压值 （高血压分级和治疗阈值和目标） 相对应的 24 小时血压值，并与指南提供的血压值进行比较。结果 Office/24 h 收缩压或舒张压始终表现出显着的线性关系，但 Pearson 相关系数有限 （从未 >0.44）。这种关系的斜率在不同治疗年份之间是叠加的，但总是明显低于未治疗个体的斜率。与指南提供的相应值相比，24 小时 BP 表现出定性和定量差异;例如，当诊室血压分别处于高血压和低治疗目标范围内时，它明显低于和高于指南的相应值。结论 在接受治疗的高血压患者中，诊室斜率/24 h 血压线性回归随时间推移是可重复的。 然而，未经治疗的个体的斜率更陡峭，这表明如果在这两种情况下分别估计，对应于诊室血压值的动态血压值的信息可能更准确。