INTRODUCTION Although there is enough pooled evidence supporting the positive association between family history of colorectal cancer (CRC) in first-degree relatives (FDRs) and the risk of CRC, synthesized data on its association with the risk of other colorectal neoplasia are lacking. Therefore, we aimed to systematically assess this issue. METHODS We searched PubMed, Web of Science, and Embase from database inception through May 9, 2024, to identify observational studies investigating the association between family history of CRC in FDRs and the risk of colorectal neoplasia (excepting CRC). Adenoma, nonadvanced adenoma (NAA), advanced adenoma (AA), and advanced neoplasia (AN) were further chosen as main outcomes because of data availability. Random-effects model was used for data synthesis. Subgroup meta-analyses were performed to evaluate the robustness of results. RESULTS Of 5,172 initial records screened, 75 studies (with 931,515 participants) were identified for analysis. Family history of CRC in FDRs was associated with increased risk of adenoma (pooled odds ratio [OR] 1.67, 95% confidence interval [CI] 1.46-1.91), NAA (pooled OR 1.35, 95% CI 1.21-1.51), AA (pooled OR 1.66, 95% CI 1.46-1.88), and AN (pooled OR 1.58, 95% CI 1.44-1.73). The positive associations persisted in all examined subgroups. The risk of adenoma (pooled OR 4.18, 95% CI 1.76-9.91), AA (pooled OR 2.42, 95% CI 1.72-3.40), and AN (pooled OR 2.00, 95% CI 1.68-2.38) was more evident among individuals with 2 or more affected FDRs. DISCUSSION Family history of CRC is associated with increased risk of adenoma, NAA, AA, and AN totally, and in all available subgroups. The findings further strengthen the necessity and importance of an intensified screening strategy for individuals with a positive family history of CRC, which is very useful for related health resource allocation and policymaking.

中文翻译：

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结直肠癌家族史和结直肠肿瘤的风险：系统评价和荟萃分析。


引言 尽管有足够的汇总证据支持一级亲属 （FDR） 的结直肠癌 （CRC） 家族史与 CRC 风险之间的正相关，但缺乏关于其与其他结直肠肿瘤风险相关的综合数据。因此，我们旨在系统地评估这个问题。方法 我们从数据库建库到 2024 年 5 月 9 日检索了 PubMed、Web of Science 和 Embase，以确定调查 FDR 中 CRC 家族史与结直肠瘤变风险（CRC 除外）之间关联的观察性研究。由于数据可得性，腺瘤、非晚期腺瘤 （NAA） 、晚期腺瘤 （AA） 和晚期肿瘤 （AN） 被进一步选择为主要结局。采用随机效应模型进行数据合成。进行亚组荟萃分析以评估结果的稳健性。结果 在筛选的 5,172 条初始记录中，确定了 75 项研究 （涉及 931,515 名参与者） 进行分析。FDR 患者 CRC 家族史与腺瘤风险增加相关 （合并比值比 [OR] 1.67,95% 置信区间 [CI] 1.46-1.91）、NAA （合并 OR 1.35,95% CI 1.21-1.51）、AA （合并 OR 1.66,95% CI 1.46-1.88） 和 AN （合并 OR 1.58,95% CI 1.44-1.73）。阳性关联在所有检查的亚组中都存在。腺瘤 （合并 OR 4.18,95% CI 1.76-9.91）、AA （合并 OR 2.42,95% CI 1.72-3.40） 和 AN （合并 OR 2.00,95% CI 1.68-2.38） 的风险在有 2 个或更多 FDR 受影响的个体中更为明显。讨论 CRC 家族史与腺瘤、 NAA、AA 和 AN 的风险完全增加相关，并且在所有可用的亚组中。 研究结果进一步加强了对 CRC 阳性家族史个体强化筛查策略的必要性和重要性，这对相关的卫生资源分配和政策制定非常有用。