The skin and cardiovascular systems are connected in unique and meaningful ways, and many diseases conventionally considered as being limited to one organ system are more closely related than previously believed. Major cardiovascular diseases and phenomena such as infective endocarditis, congestive heart failure, Kawasaki disease and thromboembolism are associated with specific skin findings, and advances in genetics, immunology and clinical epidemiology show that inflammatory dermatological diseases, such as psoriasis, have serious cardiovascular and cardiometabolic consequences. Additionally, commonly used cardiovascular therapies, such as antihypertensive medications, are associated with important cutaneous adverse effects, including photosensitivity, photocarcinogenesis and eczematous skin reactions. Moreover, systemic dermatological therapies, including retinoids, Janus kinase inhibitors and biologics, can alter the risk of cardiovascular and cardiometabolic diseases. In this Review on cardiodermatology, we provide interdisciplinary insights from dermatology and cardiology that will be of practical use to both cardiologists and generalists who manage cardiovascular and cardiometabolic diseases in patients with dermatological findings or histories. We discuss specific skin findings associated with cardiovascular diseases to aid in diagnosis; important cutaneous adverse effects of common cardiovascular therapies, for the purpose of treatment monitoring; and the effect of dermatological diseases and dermatological treatment on cardiovascular risk.

皮肤和心血管系统以独特而有意义的方式联系在一起，许多传统上被认为仅限于一个器官系统的疾病比以前认为的更密切相关。感染性心内膜炎、充血性心力衰竭、川崎病和血栓栓塞等主要心血管疾病和现象与特定的皮肤表现有关，遗传学、免疫学和临床流行病学的进展表明，炎症性皮肤病，如银屑病，具有严重的心血管和心脏代谢后果。此外，常用的心血管疗法（如抗高血压药物）与重要的皮肤不良反应有关，包括光敏性、光致癌作用和湿疹性皮肤反应。此外，全身性皮肤病疗法，包括类维生素 A、Janus 激酶抑制剂和生物制剂，可以改变心血管和心脏代谢疾病的风险。在这篇关于心脏病学的综述中，我们提供了来自皮肤病学和心脏病学的跨学科见解，这些见解将对心脏病专家和在有皮肤病学发现或病史的患者中管理心血管和心脏代谢疾病的通才具有实际用途。我们讨论与心血管疾病相关的特定皮肤发现以帮助诊断;常见心血管疗法的重要皮肤不良反应，用于治疗监测;以及皮肤病和皮肤病治疗对心血管风险的影响。