Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.

中文翻译：

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额颞叶痴呆生物医学研究的差距：呼吁以多样性和差异为重点的研究


额颞叶痴呆 （FTD） 是 65 岁之前早发性痴呆的主要原因之一，通常表现为异常行为（行为变异型 FTD）或语言障碍（原发性进行性失语症）。尽管 FTD 影响全球所有人群，但有关病理生理学和遗传学的知识主要来自在北美和西欧进行的研究。在全球范围内，FTD 的生物医学研究受到诊断机会可变的阻碍，该研究在小组的早期文章中讨论过，并且获得专业知识、资金和基础设施的机会减少。这篇观点论文由阿尔茨海默病协会国际阿尔茨海默病研究与治疗协会 （ISTAART） 的两个专业兴趣领域撰写，讨论了该领域在 FTD 基础和转化研究的跨文化方面的现状（包括侧重于流行病学、遗传学、生物标志物和治疗）。随后，它总结了解决差异和推进全球 FTD 生物医学研究的差距和需求。