The Alzheimer's Disease Neuroimaging Initiative (ADNI) Administrative Core oversees and coordinates all ADNI activities, to ensure the success and maximize the impact of ADNI in advancing Alzheimer's disease (AD) research and clinical trials. It manages finances and develops policies for data sharing, publications using ADNI data, and access to ADNI biospecimens. The Core develops and executes pilot projects to guide future ADNI activities and identifies key innovative methods for inclusion in ADNI. For ADNI4, the Administrative Core collaborates with the Engagement, Clinical, and Biomarker Cores to develop and evaluate novel, digital methods and infrastructure for participant recruitment, screening, and assessment of participants. The goal of these efforts is to enroll 500 participants, including > 50% from underrepresented populations, 40% with mild cognitive impairment, and 80% with elevated AD biomarkers. This new approach also provides a unique opportunity to validate novel methods.

中文翻译：

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ADNI 管理核心：确保 ADNI 的成功并为未来的 AD 临床试验提供信息


阿尔茨海默病神经影像学计划 （ADNI） 管理核心负责监督和协调所有 ADNI 活动，以确保 ADNI 在推进阿尔茨海默病 （AD） 研究和临床试验方面的成功并最大限度地发挥其影响。它管理财务并制定数据共享、使用 ADNI 数据发布以及访问 ADNI 生物样本的政策。该核心开发和执行试点项目，以指导未来的 ADNI 活动，并确定纳入 ADNI 的关键创新方法。对于 ADNI4，管理核心与参与、临床和生物标志物核心合作，开发和评估用于参与者招募、筛选和评估参与者的新型数字方法和基础设施。这些努力的目标是招募 500 名参与者，包括 > 50% 来自代表性不足的人群，40% 患有轻度认知障碍，80% 患有 AD 生物标志物升高。这种新方法还为验证新方法提供了独特的机会。