Immune responses by CD8 T cells are essential for control of HBV replication. Although selection of escape mutations in CD8 T cell epitopes has been previously described in HBV infection, its overall influence on HBV sequence diversity and correlation with markers of HBV replication remain unclear.

中文翻译：

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HBV 显示对 HLA I 类相关选择压力的适应水平不同，与复制标志物相关


CD8 T 细胞的免疫反应对于控制 HBV 复制至关重要。尽管之前在 HBV 感染中已经描述了 CD8 T 细胞表位中逃逸突变的选择，但其对 HBV 序列多样性的总体影响以及与 HBV 复制标志物的相关性仍不清楚。