Objective To evaluate nyctohemeral effects of topical beta-adrenoceptor blocking agents and their fixed combinations on intraocular pressure (IOP) in patients with primary open-angle glaucoma implanted with an ocular telemetry sensor. Methods 22 patients who had previously been implanted with a sulcus-based IOP sensor (eyemate) were included in this prospective clinical trial. Three classes of medications were analysed: beta-blockers (BB), fixed combination of BB and carbonic anhydrase inhibitors (BB-CAI), and combinations of BB and prostaglandin analogues (BB-PGAs). SD and IQR of IOP were calculated and used as surrogates of nyctohemeral IOP variation. Results The mean (±SD) age of patients was 67.8±6.8 years (36.4% female). A total of 50 920 IOP measurements over 4084 days from 10 eyes were included. The mean 24-hour IOP (±SE) with BB-PGA (17.3±1.1 mm Hg) was significantly (p<0.001) less than that with BB (18.8±1.1 mm Hg). Mean 24-hour IOP with BB-CAI (18.4±1.1 mm Hg) was similar (p>0.05) to that with the other two medications. Mean 24-hour SD of IOP with BB-PGA (1.9±0 .2 mm Hg) and BB-CAI (2.0±0.2 mm Hg) were significantly (p<0.05) less than that with BB (2.4±0.2 mm Hg). Mean 24-hour IQR of IOP with BB-PGA (2.3±0.4 mm Hg) was significantly less than that with both BB (3.8±0.4 mm Hg) and BB-CAI (3.2±0.4 mm Hg). Conclusion Continual IOP monitoring shows that combinations of BB-PGAs have more pronounced effects on lowering 24-hour IOP fluctuations than BB-CAIs and BBs alone. Trial registration number [NCT03651336][1]. All data relevant to the study are included in the article or uploaded as online supplemental information. Not applicable. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT03651336&atom=%2Fbjophthalmol%2Fearly%2F2024%2F11%2F06%2Fbjo-2023-324760.atom

中文翻译：

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用眼内遥测传感器测量局部 β-肾上腺素能受体阻滞剂的夜隐效应


目的 评价局部 β-肾上腺素能受体阻断剂及其固定组合对植入眼遥测传感器的原发性开角型青光眼患者眼压 （IOP） 的夜效影响。方法 22 例既往植入沟式 IOP 传感器 （eyemate） 的患者被纳入本前瞻性临床试验。分析了三类药物：β 受体阻滞剂 （BB）、BB 和碳酸酐酶抑制剂的固定组合 （BB-CAI） 以及 BB 和前列腺素类似物 （BB-PGA） 的组合。计算 IOP 的 SD 和 IQR 并用作夜喛 IOP 变化的替代物。结果 患者的平均 （±SD） 年龄为 67.8 ±岁 （6.6.8 岁 （36.4% 为女性）。共纳入 10 只眼睛在 4084 天内的 50 920 次 IOP 测量值。BB-PGA 的平均 24 小时眼压 （±SE） （17.3±1.1 mm Hg） 显著低于 BB 组 （18.8±1.1 mm Hg）。BB-CAI 的平均 24 小时眼压 （18.4±1.1 mm Hg） 与其他两种药物相似 （p>0.05）。BB-PGA （1.9±0 .2 mm Hg） 和 BB-CAI （2.0±0.2 mm Hg） 的 24 h IOP 平均 SD 显著小于 BB （2.4±0.2 mm Hg）。BB-PGA （2.3±0.4 mm Hg） 的 IOP 平均 24 小时 IQR 显著低于 BB （3.8±0.4 mm Hg） 和 BB-CAI （3.2±0.4 mm Hg）。结论 持续的 IOP 监测表明，BB-PGAs 的组合对降低 24 小时 IOP 波动的影响比单独使用 BB-CAIs 和 BBs 更明显。试验注册号 [NCT03651336][1]。与研究相关的所有数据都包含在文章中或作为在线补充信息上传。不適用。[1]：/lookup/external-ref？link_type=CLINTRIALGOV&access_num=NCT03651336&atom=%2Fbjophthalmol%2Fearly%2F2024%2F11%2F06%2Fbjo-2023-324760.原子