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Characterization of genetic landscape and novel inflammatory biomarkers in patients with adult-onset Still's disease
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2024-11-04 , DOI: 10.1002/art.43054 Joanne Topping, Leon Chang, Fatima Nadat, James A Poulter, Alice Ibbotson, Samuel Lara-Reyna, Christopher M Watson, Clive Carter, Linda P Pournara, Jan Zernicke, Rebecca L. Ross, Catherine Cargo, Paul A. Lyons, Kenneth G.C. Smith, Francesco Del Galdo, Jürgen Rech, Bruno Fautrel, Eugen Feist, Michael F. McDermott, Sinisa Savic
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2024-11-04 , DOI: 10.1002/art.43054 Joanne Topping, Leon Chang, Fatima Nadat, James A Poulter, Alice Ibbotson, Samuel Lara-Reyna, Christopher M Watson, Clive Carter, Linda P Pournara, Jan Zernicke, Rebecca L. Ross, Catherine Cargo, Paul A. Lyons, Kenneth G.C. Smith, Francesco Del Galdo, Jürgen Rech, Bruno Fautrel, Eugen Feist, Michael F. McDermott, Sinisa Savic
Adult-onset Still's disease (AOSD) is systemic autoinflammatory disorder of unknown aetiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis of a large AOSD cohort to investigate the underlying pathology and identify novel targets for potential treatment.
中文翻译:
成人发病 Still's 病患者的遗传景观和新型炎症生物标志物的表征
成人发病的斯蒂尔病 (AOSD) 是病因不明的系统性自身炎症性疾病。遗传学研究受到限制。在这里,我们对一个大型 AOSD 队列进行了详细的遗传和炎症生物标志物分析,以研究潜在病理并确定潜在治疗的新靶点。
更新日期:2024-11-05
中文翻译:
成人发病 Still's 病患者的遗传景观和新型炎症生物标志物的表征
成人发病的斯蒂尔病 (AOSD) 是病因不明的系统性自身炎症性疾病。遗传学研究受到限制。在这里,我们对一个大型 AOSD 队列进行了详细的遗传和炎症生物标志物分析,以研究潜在病理并确定潜在治疗的新靶点。