Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from bone tissues and can be classified into primary and secondary types. Due to the specificity of the bone microenvironment, the results of traditional means of treating bone tumors are often unsatisfactory, so there is an urgent need to develop new treatments for malignant bone tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis and treatment. Nanoparticles (NPs) have gained significant attention due to their versatility, making them highly suitable for applications in bone tissue engineering, advanced imaging techniques, and targeted drug delivery. For diagnosis, NPs enhance imaging contrast and sensitivity by integrating targeting ligands, which significantly improve the specific recognition and localization of tumor cells for early detection. For treatment, NPs enable targeted drug delivery, increasing drug accumulation at tumor sites while reducing systemic toxicity. In conclusion, understanding bone microenvironment and using the unique properties of NPs holds great promise in improving disease management, enhancing treatment outcomes, and ultimately improving the quality of life for patients with malignant bone tumors. Further research and development will undoubtedly contribute to the advancement of personalized medicine in the field of bone oncology.

中文翻译：

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纳米颗粒与骨微环境：骨恶性肿瘤诊治的综合评价


恶性骨肿瘤起源于骨组织，可分为原发性和继发性类型，目前临床策略难以治疗。由于骨微环境的特殊性，传统治疗骨肿瘤的方法往往不尽如人意，因此迫切需要开发新的恶性骨肿瘤治疗方法。最近，基于纳米颗粒的方法在诊断和治疗方面显示出巨大的潜力。纳米颗粒 （NPs） 因其多功能性而受到广泛关注，使其非常适合骨组织工程、高级成像技术和靶向药物递送。对于诊断，NPs 通过整合靶向配体来增强成像对比度和灵敏度，从而显着提高肿瘤细胞的特异性识别和定位，以便早期检测。在治疗方面，NPs 能够实现靶向药物递送，增加药物在肿瘤部位的积累，同时降低全身毒性。总之，了解骨微环境并利用 NPs 的独特特性在改善疾病管理、提高治疗结果并最终改善恶性骨肿瘤患者的生活质量方面具有很大的前景。进一步的研究和开发无疑将有助于骨肿瘤学领域个性化医学的进步。