Objectives To investigate associations of the ‘weekend warrior’ physical activity pattern with mild dementia. Methods Participants in the Mexico City Prospective Study were surveyed from 1998 to 2004 and re-surveyed from 2015 to 2019. Participants were asked about leisure time physical activity at baseline. Those who exercised up to once or twice per week were termed ‘weekend warriors’ and those who exercised more often were termed ‘regularly active’. A Mini Mental State Examination (MMSE) was used to assess mild dementia at re-survey. Cox models were adjusted for age, sex, education, income, blood pressure, smoking, body mass index, civil status, sleep, diet and alcohol at baseline. The attributable fraction was defined as the proportion of cases that would not exist if all adults were to exercise once or twice per week or more often. Results The analysis included 10 033 adults of mean (SD) age 51 (10) years followed for 16 (2) years. There were 2400 cases when mild dementia was defined as a score of ≤22 on the MMSE. Compared with the group that reported no sport or exercise, the hazard ratio was 0.75 (95% CI 0.61 to 0.91) in the weekend warrior group, 0.89 (95% CI 0.78 to 1.02) in the regularly active group and 0.84 (95% CI 0.75 to 0.95) in the combined group. The attributable fraction was 13% (95% CI 5% to 21%). Similar results were observed when mild dementia was defined as a score of ≤23 on the MMSE. Conclusions This longitudinal analysis suggests that the weekend warrior physical activity pattern is associated with a reduced risk of mild dementia. Data are available upon reasonable request. Mexico City Prospective Study data are available for open-access data requests. The data access policy is described online: .

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“周末战士”身体活动模式与轻度痴呆的关联：墨西哥城前瞻性研究的结果


目的 探讨“周末战士”体育活动模式与轻度痴呆的相关性。方法 墨西哥城前瞻性研究的参与者于 1998 年至 2004 年接受调查，并于 2015 年至 2019 年重新调查。参与者被问及基线时的闲暇时间身体活动。那些每周锻炼最多一到两次的人被称为 “周末勇士”，而那些更频繁锻炼的人被称为 “经常活跃”。在重新调查时，使用简易精神状态检查 （MMSE） 评估轻度痴呆。根据基线时的年龄、性别、教育、收入、血压、吸烟、体重指数、公民状况、睡眠、饮食和酒精情况调整了 Cox 模型。归因分数定义为如果所有成年人每周锻炼一次或两次或更频繁，则不存在的病例比例。结果 分析包括 10 033 名平均年龄 （SD） 为 51 （10） 岁的成年人，随访 16 （2） 年。有 2400 例轻度痴呆在 MMSE 上被定义为 ≤22 分。与报告无运动或锻炼的组相比，周末勇士组的风险比为 0.75 （95% CI 0.61 至 0.91），经常活动组为 0.89 （95% CI 0.78 至 1.02），联合组为 0.84 （95% CI 0.75 至 0.95）。归因分数为 13% （95% CI [5%， 21%]）。当轻度痴呆定义为 MMSE 评分为 ≤23 时，观察到类似的结果。结论 这种纵向分析表明，周末战士的身体活动模式与轻度痴呆风险降低有关。数据可根据合理要求提供。墨西哥城前瞻性研究数据可用于开放获取数据请求。数据访问策略在线描述：.