Magnetic resonance-guided focused ultrasound (MRgFUS) capsulotomy is a promising treatment for refractory obsessive-compulsive disorder (OCD); however, long-term clinical outcome studies are lacking. We aimed to investigate the long-term efficacy and safety of MRgFUS capsulotomy in patients with refractory OCD. Ten of the eleven patients who underwent MRgFUS capsulotomy for treatment-resistant OCD between 2013 and 2014 were included in this study. Clinical outcomes were assessed after 10 years of follow-up post-MRgFUS capsulotomy using tools such as neuropsychological test, the Frontal Systems Behavior Scale (FrSBe), and a locally developed MRgFUS-patient-centered outcomes questionnaire. After 10 years of follow-up, there was a mean improvement of 52.3% in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score. Seven out of the ten participants responded fully (Y-BOCS reduction ≥35% + CGI-I 1 or 2) to the procedure, two of whom achieved remission (Y-BOCS score ≤12 and CGI-S 1 or 2). Obsessive-compulsive symptoms and overall functioning significantly reduced and improved, respectively (Y-BOCS = 20.7 after 2 years vs. 16.4 after 10 years, p = 0.012; Global Assessment of Functioning = 57.4 after 2 years vs. 69.0 after 10 years, p = 0.011). The patients experienced significantly improved frontal lobe-related functions (FrSBe Sum before 91.0 ± 17.6 vs. after 78.6 ± 17.7, p < 0.05). No adverse effects, including cases of suicide and neurological deficits, were reported. The majority of the respondents were generally satisfied with MRgFUS capsulotomy. MRgFUS capsulotomy is an effective and safe treatment option for the treatment of severe refractory OCD with sustained efficacy even after 10 years.

磁共振引导聚焦超声 （MRgFUS） 囊切开术是一种很有前途的难治性强迫症 （OCD） 治疗方法;然而，缺乏长期的临床结局研究。我们旨在探讨 MRgFUS 囊切开术在难治性 OCD 患者中的长期疗效和安全性。2013 年至 2014 年间接受 MRgFUS 囊切开术治疗难治性 OCD 的 11 例患者中，有 10 例被纳入本研究。在 MRgFUS 囊切开术后随访 10 年后，使用神经心理学测试、额叶系统行为量表 （FrSBe） 和当地开发的以患者为中心的结果问卷等工具评估临床结果。经过 10 年的随访，耶鲁-布朗强迫症量表 （Y-BOCS） 评分平均提高了 52.3%。10 名参与者中有 7 名对手术完全反应 （Y-BOCS 降低 ≥35% + CGI-I 1 或 2），其中 2 名达到缓解 （Y-BOCS 评分 ≤12 和 CGI-S 1 或 2）。强迫症状和整体功能分别显着减少和改善 （Y-BOCS = 2 年后 20.7 vs. 10 年后 16.4，p = 0.012; 总体功能评估 = 2 年后 57.4 vs. 10 年后 69.0，p = 0.011）。 患者的额叶相关功能显著改善 （91.0 ± 17.6 之前的 FrSBe Sum vs. 78.6 ± 17.7 之后，p < 0.05）。未报告不良反应，包括自杀和神经功能缺损病例。大多数受访者对 MRgFUS 囊切开术总体满意。MRgFUS 囊切开术是治疗严重难治性 OCD 的一种有效且安全的治疗选择，即使在 10 年后仍具有持续疗效。