Diphenylprolinol silyl ethers have been successfully identified as efficient chiral amines in the enantioselective allenation reaction of terminal alkynes and 2-alkynals. This reaction provides a diverse set of chiral allenynes with excellent enantioselectivity and decent yields. Furthermore, the current protocol is also compatible for the late-stage modification of some complex bioactive molecules, highlighting its potential in drug discovery.

中文翻译：

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二苯基脯氨酸硅烷基醚对 2-炔醛对映选择性烯丙化的神奇作用


二苯基脯氨酸甲硅烷基醚已被成功鉴定为末端炔烃和 2-烷烃对映选择性烯丙化反应中的高效手性胺。该反应提供了一组多样化的手性烯丙炔，具有优异的对映选择性和不错的产量。此外，目前的方案还兼容一些复杂生物活性分子的后期修饰，突出了其在药物发现中的潜力。