The trial aimed to examine the effect of eight weeks preoperative low‐load blood flow restricted resistance training (BFR‐RT) on physical function, lower limb strength, and patient‐reported outcomes in knee OA patients 3 and 12 months after total knee arthroplasty (TKA) compared with preoperative usual care. An assessor blinded randomized controlled trial (RCT) was conducted. Eighty‐six patients scheduled for TKA who were allocated to 8 weeks BFR‐RT on the affected leg 3x/week or preoperative usual care involving no exercise (CON). Primary outcome: 30‐s sit to stand (30STS). Secondary outcomes: Timed Up&Go, 40‐m walk test (40mWT), knee range of motion (ROM) 1‐repetition maximum (1RM) leg press and knee extensor strength, maximal isometric contraction (MVIC) for the knee extensors and flexors, Knee injury and Osteoarthritis Outcome Score (KOOS), and Euroqol 5‐dimensions (EQ‐5D‐L5) questionnaire. Data were collected at baseline (12 weeks pre‐surgery), ~3 days pre‐surgery, 3 and 12 months postoperatively. Intention‐to‐treat analysis revealed no significant between‐group differences in the change from baseline to 3 and 12 months postoperatively on 30STS, TUG, or 40mFWT. Significant between‐group differences were observed at 3 but not 12 months postoperatively for the corresponding changes in 1RM leg press strength, 1RM knee extensor strength, and MVIC knee extensor favoring BFR‐RT. No between‐group differences were observed for the delta changes from baseline in knee ROM, KOOS subscales or EQ‐5D‐L5 at any postoperative time points. These findings suggest that preoperative BFR‐RT offered no superior effects compared with usual preoperative care on postoperative physical function or patient‐reported outcomes. Preoperative BFR‐RT produced amplified gains in lower limb muscle strength at 3 months postoperatively.Trial Registration: NCT04081493

中文翻译：

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全膝关节置换术前限流运动对术后身体机能、下肢力量和患者报告结果的影响：一项随机对照试验


该试验旨在检查全膝关节置换术 （TKA） 术后 3 个月和 12 个月膝关节置换术后 8 周低负荷血流限制阻力训练 （BFR-RT） 对膝关节 OA 患者身体机能、下肢力量和患者报告结局的影响与术前常规护理相比。进行了一项评估者盲法随机对照试验 （RCT）。86 名计划接受 TKA 的患者被分配到患腿 8 周 BFR-RT 3 次/周或术前不运动常规护理 （CON）。主要结果：30 秒坐立 （30STS）。次要结果：定时 Up&Go、40 m 步行测试 （40mWT）、膝关节运动范围 （ROM） 最大重复次数 （1RM） 腿推举和膝关节伸肌力量、膝伸肌和屈肌的最大等长收缩 （MVIC）、膝关节损伤和骨关节炎结果评分 （KOOS） 和 Euroqol 5 维 （EQ-5D-L5） 问卷。在基线 （术前 12 周） 、术前 ~3 天、术后 3 个月和 12 个月收集数据。意向性治疗分析显示，30STS 、 TUG 或 40mFWT 从基线到术后 3 个月和 12 个月的变化没有显着的组间差异。在术后 3 个月而不是 12 个月观察到 1RM 腿部压迫力量、1RM 膝伸肌力量和 MVIC 膝关节伸肌有利于 BFR-RT 的相应变化，组间差异显着。在任何术后时间点，膝关节 ROM 、 KOOS 分量表或 EQ-5D-L5 相对于基线的 delta 变化均未观察到组间差异。这些发现表明，与常规的术前护理相比，术前 BFR-RT 对术后身体功能或患者报告的结果没有更好的影响。 术前 BFR-RT 在术后 3 个月产生下肢肌肉力量的放大增加。试用注册：NCT04081493