Evidence indicates that ketamine is highly effective, has a lower side effect profile and is better tolerated compared to many augmentation strategies for refractory depression. This, combined with data on psychiatric treatment outcome mediators, suggests that earlier intervention with ketamine could improve outcomes for patients suffering from refractory depression.

中文翻译：

---

在难治性抑郁症的治疗层次结构中推进氯胺酮

有证据表明，氯胺酮非常有效，副作用较低，与许多难治性抑郁症的增强策略相比，耐受性更好。这与精神病治疗结果介质的数据相结合，表明氯胺酮的早期干预可以改善难治性抑郁症患者的预后。