Objectives To compare fatigue in a large multinational systemic sclerosis (SSc) cohort to general population data and identify associated sociodemographic, lifestyle and SSc disease factors. Methods Scleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean = 50; SD = 10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables. Results Among 2,385 participants (mean age 54.9 (SD = 12.6) years, 87% female, 38% diffuse SSc), mean fatigue T-score was 54.6 (SD = 11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age (-0.10 points per year, [95% CI -0.14;-0.07]), male sex (-1.67 points, [-2.96;-0.37]), non-married status (0.97 points [0.04; 1.89]), and country (reference USA; France -2.35 points [-3.48;-1.21] and UK 2.38 points [0.80; 3.97]), and lifestyle factors smoking (4.16 points [2.52; 5.80]), alcohol consumption (-0.18 points per drink per week [-0.28;-0.07]), and body-mass index (0.34 points per unit [0.27; 0.42]). Fatigue was associated with disease-related factors gastrointestinal involvement (4.21 points [2.99; 5.43]), digital ulcers (1.51 points, [0.25; 2.77]), moderate small joints contractures (1.41 points [0.13; 2.69]), rheumatoid arthritis (4.34 points [2.37–6.31]) and Sjögren’s syndrome (1.89 points [0.23; 3.55]). When pain was included in the model, its association was large (2.19 points [2.03; 2.34]) and interstitial lung disease was also associated (1.21 points [0.42; 2.00]). Conclusions In people with SSc, fatigue scores were substantially higher than the general population and associated with multiple disease factors including gastrointestinal involvement, several painful disease manifestations, and lung involvement.

中文翻译：

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系统性硬化症的疲劳水平和相关因素：对 2,385 名 SPIN 队列参与者的横断面研究


目的 将大型跨国系统性硬化症 （SSc） 队列的疲劳与一般人群数据进行比较，并确定相关的社会人口学、生活方式和 SSc 疾病因素。方法 硬皮病以患者为中心的干预网络队列参与者完成了患者报告结果测量信息系统 29 v2.0 疲劳领域。将 T 值与美国普通人群（平均值 = 50;SD = 10）。多变量线性回归用于评估与社会人口学、生活方式和疾病相关变量的关联。结果 在 2,385 名参与者 （平均年龄 54.9 （SD = 12.6） 岁，87% 女性，38% 弥漫性 SSc 中，平均疲劳 T 评分为 54.6 （SD = 11.0）;438 例 （18%） 报告轻度疲劳，641 例 （27%） 报告中度疲劳，180 例 （8%） 严重疲劳。疲劳与社会人口学因素独立相关：年龄（每年-0.10分，[95%CI -0.14;-0.07]）、男性（-1.67分，[-2.96;-0.37]）、未婚状况（0.97分[0.04;1.89]）和国家（参考美国;法国 -2.35 分 [-3.48;-1.21] 和英国 2.38 分 [0.80;3.97]），以及生活方式因素吸烟（4.16 分 [2.52;5.80]）、饮酒（每周每杯饮料 -0.18 分 [-0.28;-0.07]）和体重指数（每单位 0.34 分 [0.27;0.42]）。疲劳与疾病相关因素有关，包括胃肠道受累（4.21分[2.99;5.43]）、手指溃疡（1.51分[0.25;2.77]）、中度小关节挛缩（1.41分[0.13;2.69]）、类风湿性关节炎（4.34分[2.37-6.31]）和干燥综合征（1.89分[0.23;3.55]）。当疼痛被纳入模型时，其相关性很大（2.19 分 [2.03;2.34]），间质性肺病也相关（1.21 分 [0.42;2.00]）。 结论 SSc 患者的疲劳评分显著高于一般人群，并与多种疾病因素相关，包括胃肠道受累、几种痛苦的疾病表现和肺部受累。