We investigated the potential of the transmission line model as a digital twin of aneurysmal aorta by comparatively analyzing how a uniform lossless tube-load model were fitted to the carotid and femoral artery tonometry waveforms pertaining to (i) 79 abdominal aortic aneurysm (AAA) patients vs their matched controls (CON) and (ii) 35 AAA patients before vs after endovascular aneurysm repair (EVAR). The uniform lossless tube-load model fitted the tonometry waveforms pertaining to AAA as well as CON and EVAR. In addition, the parameters in the tube-load model exhibited physiologically explainable changes: when normalized, both pulse transit time and reflection coefficient increased with AAA and decreased after EVAR, which can be explained by the increase in arterial compliance and the decrease in arterial inertance due to the aortic expansion associated with AAA. In sum, the tube-load model may have the potential as a digital twin to enable personalized AAA monitoring.

我们通过比较分析如何将均匀无损管负载模型拟合到与 （i） 79 名腹主动脉瘤 （AAA） 患者与其匹配的对照 （CON） 和 （ii） 血管内动脉瘤修复术 （EVAR） 前后 35 名 AAA 患者。均匀无损管载荷模型拟合了与 AAA 以及 CON 和 EVAR 相关的眼压波形。此外，管载荷模型中的参数表现出生理学上可解释的变化：当归一化时，脉搏传输时间和反射系数都随着 AAA 的增加而增加，而 EVAR 后降低，这可以通过动脉顺应性的增加和动脉惰性的降低来解释与 AAA 相关的主动脉扩张。总之，管载荷模型可能具有作为数字孪生的潜力，以实现个性化的 AAA 监测。