Minocycline is a commonly used drug for adjunctive therapy in periodontal disease. However, the current mainstream local medications primarily rely on intra‐pocket administration, which, while avoiding the side effects of traditional systemic drugs, presents challenges such as inconvenience, discomfort, and the need for professional assistance, thus affecting patient compliance. Herein, we introduce a minocycline‐loaded dissolvable microneedle (Mino‐DMN) patch that allows for local and efficient delivery of minocycline to gingiva for the treatment of periodontitis. A two‐step casting micro‐molding process involving vacuum drying and freeze drying is employed to concentrate minocycline in the microneedle part and limit its diffusion into the patch backing. The resulting Mino‐DMN patch features an array of minocycline‐enriched gelatin MNs with a porous HA patch backing. The microneedles can penetrate into gingiva with enough mechanical strength and quickly release minocycline into the gingival tissue, ensuring prolonged local residence of the drug and minimizing its loss to saliva. In vivo experiments show Mino‐DMN inhibits pro‐inflammatory factors, promotes anti‐inflammatory factors, and stimulates bone formation, surpassing topical application and comparable to the inconvenient and discomfort administration of Periocline®. This proposed Mino‐DMN offers a simple, efficient, user‐friendly strategy for the adjunctive treatment of periodontal disease.

中文翻译：

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使用可溶解的微针贴剂在牙龈中轻松部署米诺环素以辅助治疗牙周病


米诺环素是牙周病辅助治疗的常用药物。然而，目前主流的本地药物主要依赖于口袋内给药，这在避免了传统全身性药物的副作用的同时，带来了不便、不适和需要专业帮助等挑战，从而影响患者的依从性。在此，我们介绍了一种负载米诺环素的可溶性微针 （Mino-DMN） 贴剂，它允许将米诺环素局部有效地输送到牙龈以治疗牙周炎。采用涉及真空干燥和冷冻干燥的两步铸造微成型工艺，将米诺环素浓缩在微针部分并限制其扩散到贴剂背衬中。所得的 Mino-DMN 贴剂具有一系列富含米诺环素的明胶 MNs，具有多孔 HA 贴剂背衬。微针可以以足够的机械强度渗透到牙龈中，并迅速将米诺环素释放到牙龈组织中，确保药物在局部停留的时间延长，并最大限度地减少其对唾液的损失。体内实验表明，Mino-DMN 抑制促炎因子，促进抗炎因子，刺激骨形成，超越局部应用，可与 Periocline® 的不便和不适给药相媲美。这种提出的 Mino-DMN 为牙周病的辅助治疗提供了一种简单、高效、用户友好的策略。