The biodegradability and biocompatibility of Mg alloys have rendered them favorable for cranial reconstruction applications. However, their rapid degradation rate has limited widespread use. In this study, we developed a Mg alloy -based mesh designed for calvarial bone defect reconstruction. We modulated the bone formation through the controlled degradation rate of the Mg alloy mesh. To achieve this, the Mg alloy mesh was coated with 2 types of coatings: Zn-d/Ca-P and Zn-d/Ca-P/P. Our findings revealed that, in comparison to the uncoated Mg alloy, both Zn-d/Ca-P and Zn-d/Ca-P/P coatings significantly reduced the degradation rate. The biocompatibility of the coated meshes improved markedly. With the Zn-d/Ca-P coating, there was not only an augmentation in the osteogenic potential of the Mg mesh but also an enhancement in angiogenic capacity. These meshed Mg samples were subsequently implanted into calvarial defects in rats. Bone regeneration was accelerated in specimens treated with Zn-d/Ca-P and Zn-d/Ca-P/P coatings compared to those with the bare Mg mesh. Furthermore, the in vivo assessments indicated that the coated meshes promoted angiogenesis. Nonetheless, the degradation rate of the Zn-d/Ca-P/P coating was slower than that of Zn-B/Ca-P. For applications requiring prolonged mechanical support, the Zn-d/Ca-P/P coating on Mg alloy is recommended, whereas the Zn-d/Ca-P coating is advisable for rapid regeneration where extended mechanical support is not critical.

中文翻译：

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用于颅骨缺损重建的 Mg 网片的编排降解行为


Mg 合金的生物降解性和生物相容性使其有利于颅骨重建应用。然而，它们的快速降解速度限制了其广泛使用。在这项研究中，我们开发了一种用于颅骨缺损重建的基于 Mg 合金的网片。我们通过 Mg 合金网的受控降解速率来调节骨形成。为此，Mg 合金网格涂有 2 种类型的涂层：Zn-d/Ca-P 和 Zn-d/Ca-P/P。我们的研究结果表明，与未涂层的 Mg 合金相比，Zn-d/Ca-P 和 Zn-d/Ca-P/P 涂层都显著降低了降解速率。涂层网片的生物相容性显著提高。使用 Zn-d/Ca-P 涂层，不仅 Mg 网的成骨电位增加，而且血管生成能力也有所增强。这些网状 Mg 样品随后被植入大鼠的颅骨缺损中。与裸 Mg 网相比，用 Zn-d/Ca-P 和 Zn-d/Ca-P/P 涂层处理的标本的骨再生加速。此外，体内评估表明涂层网片促进血管生成。尽管如此，Zn-d/Ca-P/P 涂层的降解速率比 Zn-B/Ca-P 慢。对于需要长时间机械支撑的应用，建议在 Mg 合金上使用 Zn-d/Ca-P/P 涂层，而 Zn-d/Ca-P 涂层则适用于扩展机械支撑不重要的快速再生。