Anti–citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti–modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined. We therefore investigated the presence of several AMPA (ACPA, anti–carbamylated protein antibodies [anti-CarP], and anti–acetylated protein antibodies [AAPA]) at different mucosal sites, including the intestinal tract.

中文翻译：

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类风湿性关节炎中部位特异性粘膜自身抗体分泌的证据


已在痰液和唾液中检测到抗瓜氨酸蛋白抗体 （ACPA），表明类风湿性关节炎 （RA） 患者的粘膜部位可以产生抗修饰蛋白抗体 （AMPA）。然而，人体最大的粘膜隔室，即肠道，尚未得到检查。因此，我们调查了几种 AMPA （ACPA、抗氨基甲酰化蛋白抗体 [anti-CarP] 和抗乙酰化蛋白抗体 [AAPA]）在不同粘膜部位（包括肠道）的存在。