Debate persists regarding the potential carcinogenicity of aspartame as suggested by experimental studies. Therefore, we prospectively evaluated whether aspartame consumption is associated with breast cancer risk in the Nurses’ Health Study (NHS) and Nurses’ Health study II (NHSII). We used Cox models to calculate HRs and 95% CIs. During up to 30 years of follow-up with 4-yearly assessments of intake, we documented 10,814 invasive breast cancer cases. Overall, there was no association between aspartame consumption and invasive breast cancer risk (HR per 200 mg/day [approximately one 12 oz serving of diet soda] = 1.00 (95% CI 0.98, 1.03). We observed similar lack of associations after excluding cases occurring in the first 10 years of follow-up (n = 3,125) (HR per 200 mg/day 1.00, 95% CI 0.97, 1.03). In these cohorts, aspartame consumption did not increase breast cancer risk.

中文翻译：

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护士健康研究中阿斯巴甜的消费量和患乳腺癌的风险


正如实验研究表明的那样，关于阿斯巴甜的潜在致癌性的争论仍然存在。因此，我们在护士健康研究 （NHS） 和护士健康研究 II （NHSII） 中前瞻性评估了阿斯巴甜消费是否与乳腺癌风险相关。我们使用 Cox 模型计算 HR 和 95% CI。在长达 30 年的随访和 4 年的摄入量评估中，我们记录了 10,814 例浸润性乳腺癌病例。总体而言，阿斯巴甜消费与浸润性乳腺癌风险之间没有关联（每 200 毫克/天的 HR [大约一份 12 盎司的无糖苏打水] = 1.00 （95% CI 0.98， 1.03）。在排除随访前 10 年发生的病例后，我们观察到类似的缺乏关联 （n = 3,125） （HR per 200 mg/day 1.00,95% CI 0.97,1.03）。在这些队列中，阿斯巴甜消费不会增加患乳腺癌的风险。