This randomized clinical trial evaluated the effectiveness of short, digital interventions in improving physical activity and pain for individuals with knee osteoarthritis. We compared a digital mindset intervention, focusing on adaptive mindsets (e.g., osteoarthritis is manageable), to a digital education intervention and a no-intervention group. 408 participants with knee osteoarthritis completed the study online in the US. The mindset intervention significantly improved mindsets compared to both other groups (P < 0.001) and increased physical activity levels more than the no-intervention group (mean = 28.6 points, P = 0.001), but pain reduction was not significant. The mindset group also showed significantly greater improvements in the perceived need for surgery, self-imposed physical limitations, fear of movement, and self-efficacy than the no-intervention and education groups. This trial demonstrates the effectiveness of brief digital interventions in educating about osteoarthritis and further highlights the additional benefits of improving mindsets to transform patients’ approach to disease management. The study was prospectively registered (ClinicalTrials.gov: NCT05698368, 2023-01-26).

这项随机临床试验评估了短期数字干预在改善膝骨关节炎患者身体活动和疼痛方面的有效性。我们将专注于适应性心态（例如，骨关节炎是可控的）的数字心态干预与数字教育干预和无干预组进行了比较。408 名膝骨关节炎参与者在美国在线完成了这项研究。与其他两组相比，心态干预显著改善了心态 （P < 0.001），并且比无干预组增加了更多的身体活动水平 （平均值 = 28.6 分，P = 0.001），但疼痛减轻不显著。与无干预组和教育组相比，心态组在感知手术需求、自我施加的身体限制、对运动的恐惧和自我效能感方面也显示出显着更大的改善。该试验证明了简短的数字干预在骨关节炎教育方面的有效性，并进一步强调了改善心态以改变患者疾病管理方法的额外好处。该研究进行了前瞻性注册 （ClinicalTrials.gov： NCT05698368， 2023-01-26）。