OBJECTIVE Patients with inflammatory articular diseases, such as psoriatic arthritis (PsA), report weather changes in their symptoms. Our objective was to investigate the correlation between weather variation, disease activity (DA), and patient-reported outcomes (PROs) in patients with PsA. METHODS Hourly measurements of temperature, relative humidity, and pressure were obtained from 2015 to 2020 in Montreal (through Environment Canada) and were matched with DA and PROs of patients with PsA enrolled in Rhumadata. The differences in mean DA and PROs were examined between winter and summer. Pearson correlation coefficients were calculated between clinical profile and weather measurements. RESULTS Among patients with PsA, 2665 PROs were collected for a total of 858 patients. The Clinical Disease Activity Index (P = 0.001) and Simplified Disease Activity Index (P < 0.001) were lower in winter. In summer, positive correlations were found between humidity and symptoms (using patient global assessment, fatigue, pain, C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index), whereas negative correlations between temperature and Health Assessment Questionnaire-Disability Index were reported. In winter, positive correlations were observed between temperature, fatigue, and pain. CONCLUSION This is the first study to investigate weather variations through subjective and objective PROs matched with patients with PsA. Statistically significant differences in clinical profile were evident between winter and summer, as well as in their correlation with weather measurements. However, these distinctions lack clinical significance, suggesting a small impact on patients with PsA.

中文翻译：

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银屑病关节炎疾病活动和患者报告结果的天气变化的真实世界分析。


目的 患有炎症性关节疾病的患者，例如银屑病关节炎 （PsA），报告其症状的天气变化。我们的目的是研究 PsA 患者天气变化、疾病活动 （DA） 和患者报告结果 （PROs） 之间的相关性。方法 从 2015 年到 2020 年，在蒙特利尔（通过加拿大环境部）获得了每小时的温度、相对湿度和压力测量值，并与 Rhumadata 中登记的 PsA 患者的 DA 和 PRO 相匹配。检查冬季和夏季平均 DA 和 PRO 的差异。计算临床概况和天气测量之间的 Pearson 相关系数。结果 在 PsA 患者中，共收集了 2665 例 PROs，共 858 例患者。冬季临床疾病活动指数 （P = 0.001） 和简化疾病活动指数 （P < 0.001） 较低。在夏季，湿度与症状呈正相关 （使用患者整体评估、疲劳、疼痛、C 反应蛋白、Bath 强直性脊柱炎疾病活动指数、Bath 强直性脊柱炎功能指数），而温度与健康评估问卷-残疾指数呈负相关。在冬季，观察到温度、疲劳和疼痛呈正相关。结论 这是第一项通过与 PsA 患者匹配的主观和客观 PRO 来调查天气变化的研究。冬季和夏季之间临床特征的统计学显着差异以及它们与天气测量的相关性是明显的。然而，这些区别缺乏临床意义，表明对 PsA 患者的影响很小。