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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2024 , DOI: 10.1172/jci176567 Chester J. Kao, Soren Charmsaz, Stephanie L. Alden, Madelena Brancati, Howard L. Li, Aanika Balaji, Kabeer Munjal, Kathryn Howe, Sarah Mitchell, James Leatherman, Ervin Griffin, Mari Nakazawa, Hua-Ling Tsai, Ludmila Danilova, Chris Thoburn, Jennifer Gizzi, Nicole E. Gross, Alexei Hernandez, Erin M. Coyne, Sarah M. Shin, Jayalaxmi Suresh Babu, George W. Apostol, Jennifer Durham, Brian J. Christmas, Maximilian F. Konig, Evan J. Lipson, Jarushka Naidoo, Laura C. Cappelli, Aliyah Pabani, Yasser Ged, Marina Baretti, Julie Brahmer, Jean Hoffman-Censits, Tanguy Y. Seiwert, Rachel Garonce-Hediger, Aditi Guha, Sanjay Bansal, Laura Tang, Elizabeth M. Jaffee, G. Scott Chandler, Rajat Mohindra, Won Jin Ho, Mark Yarchoan
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2024 , DOI: 10.1172/jci176567 Chester J. Kao, Soren Charmsaz, Stephanie L. Alden, Madelena Brancati, Howard L. Li, Aanika Balaji, Kabeer Munjal, Kathryn Howe, Sarah Mitchell, James Leatherman, Ervin Griffin, Mari Nakazawa, Hua-Ling Tsai, Ludmila Danilova, Chris Thoburn, Jennifer Gizzi, Nicole E. Gross, Alexei Hernandez, Erin M. Coyne, Sarah M. Shin, Jayalaxmi Suresh Babu, George W. Apostol, Jennifer Durham, Brian J. Christmas, Maximilian F. Konig, Evan J. Lipson, Jarushka Naidoo, Laura C. Cappelli, Aliyah Pabani, Yasser Ged, Marina Baretti, Julie Brahmer, Jean Hoffman-Censits, Tanguy Y. Seiwert, Rachel Garonce-Hediger, Aditi Guha, Sanjay Bansal, Laura Tang, Elizabeth M. Jaffee, G. Scott Chandler, Rajat Mohindra, Won Jin Ho, Mark Yarchoan
BACKGROUND. Immune-related adverse events (irAEs) and their associated morbidity/mortality are a key concern for patients receiving immune checkpoint inhibitors (ICIs). Prospective evaluation of the drivers of irAEs in a diverse pan-tumor cohort is needed to identify patients at greatest risk and to develop rational treatment and interception strategies.
中文翻译:
免疫治疗中接受免疫治疗的实体瘤个体的免疫相关事件与 Th17 和 Th2 特征相关
背景。 免疫相关不良事件 (irAEs) 及其相关的发病率/死亡率是接受免疫检查点抑制剂 (ICI) 的患者的主要关注点。需要对不同泛肿瘤队列中 irAEs 的驱动因素进行前瞻性评估,以确定风险最大的患者并制定合理的治疗和拦截策略。
更新日期:2024-10-16
中文翻译:
免疫治疗中接受免疫治疗的实体瘤个体的免疫相关事件与 Th17 和 Th2 特征相关
背景。 免疫相关不良事件 (irAEs) 及其相关的发病率/死亡率是接受免疫检查点抑制剂 (ICI) 的患者的主要关注点。需要对不同泛肿瘤队列中 irAEs 的驱动因素进行前瞻性评估,以确定风险最大的患者并制定合理的治疗和拦截策略。