PURPOSE The gradings of complete retinal pigment epithelium and outer retinal atrophy (cRORA) and incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) on spectral domain optical coherence tomography (SD-OCT) B-scans were compared with the grading of persistent choroidal hypertransmission defects (hyperTDs) on swept-source OCT angiography (SS-OCTA) en face images. DESIGN Comparative diagnostic analysis of prospective study data METHODS: Patients with late nonexudative AMD underwent same day 6 × 6 mm macular scans using both SD-OCT (Spectralis® Heidelberg, 512 × 97, ART:9) and SS-OCTA (PLEX® Elite 9000, Carl Zeiss Meditec, 500 × 500 angio pattern) instruments. SS-OCTA and SD-OCT en face images were generated from a sub-retinal pigment epithelium slab positioned 64-400 μm below Bruch's membrane. SD-OCT B-scan gradings, which included an inspection of neighboring B-scans for the diagnosis of cRORA and iRORA, were performed at the Moran Eye Center, while gradings of en face images to identify persistent choroidal hyperTDs were performed at the Bascom Palmer Eye Institute and Tel Aviv Medical Center. RESULTS There was a high degree of agreement (99.6%) between the gradings of cRORA lesions and persistent hyperTDs. However, 27.4% of iRORA lesions were found to be contained within persistent hyperTDs. This discrepancy was due to the finding that 27.5% of iRORA lesions were diagnosed as having a greatest linear horizontal dimension of < 250 µm on B-scans, but on en face images, these B-scan defined iRORA lesions were found to have a greatest linear dimensions in the non-horizontal dimension that were ≥ 250 µm. CONCLUSION This report demonstrates the benefits of using en face OCT imaging to identify cRORA lesions and highlights the need to acquire dense raster B-scans with the grading neighboring B-scans when identifying iRORA lesions to assess the full extent of the iRORA lesions in the non-horizontal dimension. Even though neighboring B-scans were inspected, 27.5% of iRORA lesions were actually part of larger cRORA lesions when graded using an en face strategy.

中文翻译：

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OCT B 扫描和 En Face 成像诊断年龄相关性黄斑变性早期黄斑萎缩的比较。


目的 将光谱域光学相干断层扫描 （SD-OCT） B 扫描上完全视网膜色素上皮和视网膜外萎缩 （cRORA） 和不完全视网膜色素上皮和视网膜外萎缩 （iRORA） 的分级与扫描源 OCT 血管造影 （SS-OCTA） 上持续性脉络膜超传输缺陷 （hyperTD） 的分级进行了比较面部图像。设计 前瞻性研究数据的比较诊断分析方法： 晚期非渗出性 AMD 患者使用 SD-OCT （Spectralis® Heidelberg， 512 × 97， ART：9） 和 SS-OCTA （PLEX® Elite 9000， Carl Zeiss Meditec， 500 × 500 血管模式） 仪器进行当天 6 × 6 mm 黄斑扫描。SS-OCTA 和 SD-OCT en 面部图像由位于 Bruch 膜下方 64-400 μm 的视网膜下色素上皮板生成。SD-OCT B 扫描分级，包括检查相邻的 B 扫描以诊断 cRORA 和 iRORA，在 Moran 眼科中心进行，而 en 面部图像分级以识别持续性脉络膜高 TD 在 Bascom Palmer 眼科研究所和特拉维夫医疗中心进行。结果 cRORA 病变分级与持续性 hyperTDs 之间高度一致 （99.6%）。然而，发现 27.4% 的 iRORA 病变包含在持续性 hyperTD 中。这种差异是由于发现 27.5% 的 iRORA 病灶在 B 扫描中被诊断为具有 < 250 μm 的最大线性水平尺寸，但在面部图像上，发现这些 B 扫描定义的 iRORA 病灶在非水平维度上具有最大的线性尺寸，≥ 250 μm。 结论 本报告展示了使用面部 OCT 成像识别 cRORA 病灶的好处，并强调了在识别 iRORA 病灶时需要获取密集的光栅 B 扫描和分级相邻的 B 扫描，以评估非水平维度上 iRORA 病灶的全部范围。尽管检查了邻近的 B 扫描，但在使用 en face 策略进行分级时，27.5% 的 iRORA 病灶实际上是较大 cRORA 病灶的一部分。