Streptococcus pyogenes, or group A streptococcus, remains a major global pathogen, responsible for a wide spectrum of diseases ranging from pharyngitis to severe invasive group A streptococcus (iGAS) infections.¹ Central to the virulence of S pyogenes are its many anti-phagocytic proteins and toxins, including the superantigens. Emergence of new S pyogenes lineages are associated with both increased iGAS case frequency and mortality, often linked to changes in toxin production.²

中文翻译：

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关闭毒素的时间：辅助抑制 A 组链球菌


化脓性链球菌或 A 组链球菌仍然是一种主要的全球病原体，导致从咽炎到严重侵袭性 A 组链球菌 （iGAS） 感染等多种疾病。¹ 化脓性链球菌毒力的核心是其许多抗吞噬蛋白和毒素，包括超抗原。新的化脓性链球菌谱系的出现与 iGAS 病例频率和死亡率增加有关，通常与毒素产生的变化有关。^{阿拉伯数字}