BACKGROUND Adolescent and young adult (AYA) cancer incidence rates are rising, and survivors are at risk for numerous cancer- and treatment-related consequences. Despite growing attention to this population, prevalence estimates are lacking. PURPOSE To estimate the number of individuals living in the United States with a history of cancer diagnosed during the AYA period. METHODS Prevalence of cancer survivors diagnosed between the ages of 15 and 39 years was estimated using data from the Surveillance, Epidemiology, and End Results (SEER) program as of January 1, 2020. Limited duration prevalence data were also used to generate complete prevalence by sex, years since diagnosis (0-<1, 1-<5, 5-<10, 10-<15, 15-<20, 20+), and attained age (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70+) for the 15 most common AYA cancer sites. RESULTS There were an estimated 2,111,838 survivors of AYA cancers in the United States as of January 1, 2020. More survivors were female (66%) and long-term (>5 years from diagnosis, 83%) or very long-term survivors (>10 years from diagnosis, 68.8%). A large percentage (44%) were more than 20 years from diagnosis. The most common cancer sites among females were breast (24%) and thyroid cancers (23%) and, among males, testicular cancer (31%). Across the population, the highest percentage of survivors of AYA cancers were 40- to 49-years of age (25.3%). CONCLUSION There are over 2.1 million cancer survivors diagnosed in the AYA period who are living in the United States; most are more than 10 years from diagnosis.

中文翻译：

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在美国，青春期和青年期诊断的癌症幸存者的患病率


背景 青少年和年轻成人 （AYA） 癌症的发病率正在上升，幸存者面临许多癌症和治疗相关后果的风险。尽管对这一人群的关注日益增加，但缺乏患病率估计。目的 估计在 AYA 期间被诊断出有癌症病史的美国居民人数。方法 使用截至 2020 年 1 月 1 日的监测、流行病学和最终结果 （SEER） 计划的数据估计 15 至 39 岁之间诊断的癌症幸存者的患病率。有限持续时间患病率数据还用于按性别、诊断后年份 （0-<1， 1-<5， 5-<10， 10-<15， 15-<20， 20+） 和达到年龄 （15-19， 20-29， 30-39， 40-49， 50-59， 60-69， 70+） 生成 15 个最常见的 AYA 癌症部位的完整患病率。结果截至 2020 年 1 月 1 日，美国估计有 2,111,838 名 AYA 癌症幸存者。更多的幸存者是女性 （66%） 和长期 （>5 诊断后，83%） 或非常长期的幸存者 （>诊断后 10 年，68.8%）。很大一部分 （44%） 患者在诊断后超过 20 年。女性最常见的癌症部位是乳腺癌 （24%） 和甲状腺癌 （23%），男性最常见的睾丸癌 （31%）。在整个人群中，40 至 49 岁的 AYA 癌症幸存者比例最高 （25.3%）。结论 在 AYA 期间被诊断出患有癌症的幸存者超过 210 万，他们居住在美国;大多数患者在诊断后超过 10 年。