Previous studies have indicated associations between maternal mental disorders and adverse birth outcomes; however, these studies mainly focus on certain types of mental disorders, rather than the whole spectrum.

We aimed to conduct a broad study examining all maternal mental disorder types and adverse neonatal outcomes which is needed to provide a more complete understanding of the associations.

We included 1 132 757 liveborn singletons born between 1997 and 2015 in Denmark. We compared children of mothers with a past (>2 years prior to conception; n = 48 646), recent (2 years prior to conception and during pregnancy; n = 15 899) or persistent (both past and recent; n = 10 905) diagnosis of any mental disorder, with children of mothers with no mental disorder diagnosis before the index delivery (n = 1 057 307). We also considered different types of mental disorders. We calculated odds ratios and 95% CIs of low birthweight, preterm birth, small for gestational age, low Apgar score, Caesarean delivery and neonatal death.

Odds ratios for children exposed to past, recent and persistent maternal mental disorders suggested an increased risk for almost all adverse neonatal outcomes. Estimates were highest for children in the ‘persistent’ group for all outcomes, with the exception of the association between persistent maternal mental disorders and neonatal death (odds ratio 0.96, 0.62–1.48).

Our study provides evidence for increased risk of multiple adverse neonatal outcomes among children of mothers with mental disorders, highlighting the need for close monitoring and support for women with mental disorders.

先前的研究表明，孕产妇精神障碍与不良分娩结局之间存在关联;然而，这些研究主要集中在某些类型的精神障碍上，而不是整个范围。

我们旨在进行一项广泛的研究，检查所有孕产妇精神障碍类型和不良新生儿结局，这是提供更全面了解相关性所必需的。

我们纳入了 1 132 757 名 1997 年至 2015 年间在丹麦出生的活产单身人士。我们比较了母亲有过去（受孕前 3E2 年;n = 48 646），最近（受孕前 2 年和怀孕期间;n = 15 899）或持续性（过去和近期;n = 10 905） 诊断为任何精神障碍，母亲在指数分娩前未诊断为精神障碍的孩子 （n = 1 057 307）。我们还考虑了不同类型的精神障碍。我们计算了低出生体重、早产、小于胎龄儿、低 Apgar 评分、剖宫产和新生儿死亡的比值比和 95% CI。

暴露于既往、近期和持续性孕产妇精神障碍的儿童的比值比表明，几乎所有不良新生儿结局的风险增加。除持续性孕产妇精神障碍与新生儿死亡之间的关联外，所有结局中“持续性”组儿童的估计值最高（比值比 0.96,0.62-1.48）。

我们的研究提供了证据，证明患有精神障碍的母亲的孩子发生多种不良新生儿结局的风险增加，强调了对患有精神障碍的女性进行密切监测和支持的必要性。