The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.

中文翻译：

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成人危重患者体外膜肺氧合抗菌药物剂量的叙述性回顾


接受体外膜肺氧合（ECMO）的危重患者抗菌药物的最佳剂量策略尚不清楚。我们对ECMO对抗菌药物药代动力学和药效学影响的现有文献进行了全面回顾，这些抗菌药物包括危重患者常用的抗菌药物、抗真菌药物和抗病毒药物。我们的目标是为临床医生提供针对这些患者的经验性给药策略的实用指导。最后，我们讨论了治疗药物监测的重要性、当前文献的局限性以及未来的研究方向。