Summary: Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models. See related article by Sandoval et al., p. 1901

中文翻译：

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消除扭结：武装自然杀伤细胞对抗卵巢癌


摘要： 改善肿瘤免疫微环境是改善癌症患者治疗结果的关键策略。Sandoval 及其同事证明，铁螯合可增强 I 型 IFN 的产生，促进 NK 细胞肿瘤的运输和活化，并与化疗药物顺铂协同作用，以减少小鼠模型中的转移性卵巢癌进展。参见 Sandoval 等人的相关文章，第 1901 页