Regarding the current materials used for suture anchors for rotator cuff repair, there are still limitations in terms of degradability, mechanical properties, and bioactivities in clinical applications. Magnesium alloys have preliminarily been shown to promote tendon-bone healing with good prospects for application as anchor materials. However, the design of anchor structures for the degradation characteristics of magnesium alloy materials has not been considered, which is critical for the practical application of magnesium alloy anchors. The mechanism by which magnesium promotes tendon bone healing remains to be clarified. Here, we proposed a novel split hollowed magnesium alloy suture anchors for the repair of rabbit rotator cuff injury. We found that novel split hollowed magnesium alloy anchors structure effectively solved the problem of failure due to degradation of traditional eyelet structure, providing reliable suture fixation. The open architecture facilitates the metabolic resorption of the degradation products of and promotes the ingrowth of bone tissue. Histological staining showed that magnesium anchors have better ability to promote regeneration at the fibrocartilage interface compared to PLLA anchors. The higher expression of fibrocartilage markers (Aggrecan, COL2A1, and Sox9) at the tendon-bone interface in magnesium anchors, which promotes chondrocyte differentiation at the tendon-bone interface and matrix formation, which is more conducive to achieving regeneration and maturation of fibrocartilage enthesis. Hence, this study provides a basis for further research on the clinical application of degradable magnesium alloy suture anchors.

中文翻译：

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一种新颖设计的镁合金缝合锚栓在兔肩袖修复中促进纤维软骨附着点再生


关于目前用于肩袖修复的缝合锚固件的材料，在临床应用中在降解性、机械性能和生物活性方面仍然存在局限性。镁合金已初步证明可以促进肌腱-骨骼愈合，具有良好的应用前景。然而，尚未考虑针对镁合金材料降解特性的锚杆结构设计，这对镁合金锚杆的实际应用至关重要。镁促进肌腱骨愈合的机制仍有待阐明。在这里，我们提出了一种新型的分体式空心镁合金缝合锚栓，用于修复兔子肩袖损伤。我们发现，新颖的分体式空心镁合金锚栓结构有效解决了传统孔眼结构退化导致的失效问题，提供了可靠的缝合固定。开放式结构促进骨组织降解产物的代谢吸收并促进骨组织的内生。组织学染色显示，与 PLLA 锚相比，镁锚在促进纤维软骨界面再生的能力更好。镁锚在肌腱-骨界面处纤维软骨标志物 （Aggrecan、COL2A1 和 Sox9） 的表达较高，促进肌腱-骨界面处软骨细胞分化和基质形成，更有利于实现纤维软骨附着点的再生和成熟。因此，本研究为可降解镁合金缝合锚栓的临床应用进一步研究提供了依据。