While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity.

中文翻译：

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与氯氮平相关的死亡率：证据是什么？

虽然氯氮平有风险，但死亡的相对风险被高估了。英国药物警戒计划是有效的，但由于报告差异，与其他药物的比较可能会产生误导。氯氮平实际上降低了死亡率，部分是通过减少与精神分裂症相关的自杀，但可预防的死亡仍然发生。氯氮平应更早、更广泛地使用，但应该有更好的监测和更好的毒性管理。