Between 10 and 30% of people infected with SARS-CoV-2 suffer from post-acute sequelae of SARS-CoV-2 infection (PASC; also known as long COVID). PASC can persist for months or years and includes conditions such as cardiovascular diseases, cerebrovascular diseases and metabolic diseases including type 2 diabetes. A new study reports a nonhuman primate model of metabolic PASC using SARS-CoV-2-infected African green monkeys (AGMs), which exhibits similar features to human metabolic PASC and can be explored to identify therapies. SARS-CoV-2 infection in AGMs was associated with early-onset hyperglycemia, which persisted for at least 18 weeks post-infection. Hyperglycemia was associated with a dysregulated blood chemokine signature. Infected animals also showed increased liver glycogen levels, which correlated with blood glucose levels.

Original reference: Palmer, C.S. et al. Nat. Commun. 15, 6664 (2024)

10% 至 30% 的 SARS-CoV-2 感染者患有 SARS-CoV-2 感染后急性后遗症（PASC；也称为长期新冠肺炎）。 PASC 可以持续数月或数年，包括心血管疾病、脑血管疾病和代谢疾病（包括 2 型糖尿病）等疾病。一项新的研究报告了使用感染 SARS-CoV-2 的非洲绿猴 (AGM) 建立的非人类灵长类代谢 PASC 模型，该模型表现出与人类代谢 PASC 相似的特征，可以探索以确定治疗方法。 AGM 中的 SARS-CoV-2 感染与早发性高血糖有关，这种情况在感染后持续至少 18 周。高血糖与血液趋化因子特征失调有关。受感染的动物还表现出肝糖原水平升高，这与血糖水平相关。

原始参考文献： Palmer, CS 等人。夜晚。交流。 15 , 6664 (2024)