Sonopiezoelectric therapy harnesses piezoelectric materials to efficiently generate destructive reactive oxygen species when exposed to ultrasound. This innovative approach shows promise for tumor treatment by combining precise targeting of tumor sites through noninvasive ultrasound control with high reactive oxygen species generation capabilities via the piezoelectric effect. This study utilizes a theoretical-guided method to manipulate atomic vacancy defects and regulate the Peierls distortion in 1T′-ReS₂ nanosheets, thereby imparting them with sonopiezoelectric properties not inherent to the original material. Furthermore, the plentiful unsaturated sites of ReS₂ nanosheets endow them with excellent catalase- and peroxidase-mimicking activities. The reactive oxygen species generation by the engineered ReS₂ nanosheets also leads to the depletion of glutathione. These capabilities are leveraged for tumor ferroptosis therapy via the classical pathway involving the 7-member 11-glutathione-GPX4 signaling axis, alongside the downregulation of dihydroorotate dehydrogenase and ferritin levels and the upregulation of fatty acid CoA ligase 4 expression. This showcases the innovative approach and potential applications of employing 1T′-ReS₂ nanosheets in cancer treatment through theoretical design and materials engineering.

中文翻译：

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通过理论引导空位操纵 Peierls 畸变赋予 1T′-ReS2 纳米片超声压电特性用于肿瘤铁死亡治疗


超声压电疗法利用压电材料在暴露于超声波时有效地产生破坏性的活性氧。这种创新方法将通过无创超声控制精确定位肿瘤部位与通过压电效应产生高活性氧的能力相结合，为肿瘤治疗带来了希望。这项研究利用理论指导的方法来操纵原子空位缺陷并调节 1T'-ReS ₂纳米片中的 Peierls 畸变，从而赋予它们原始材料所不具备的声压电特性。此外，ReS ₂纳米片的大量不饱和位点赋予它们优异的过氧化氢酶和过氧化物酶模拟活性。工程化 ReS ₂纳米片产生的活性氧也会导致谷胱甘肽的消耗。这些功能通过涉及 7 成员 11-谷胱甘肽-GPX4 信号轴的经典途径，以及二氢乳清酸脱氢酶和铁蛋白水平的下调以及脂肪酸 CoA 连接酶 4 表达的上调，用于肿瘤铁死亡治疗。这展示了通过理论设计和材料工程在癌症治疗中采用1T'-ReS ₂纳米片的创新方法和潜在应用。