Diols are important platform chemicals with a wide range of applications in the fields of chemical and pharmaceutical industries, food, feed and cosmetics. In particular, 1,3-propanediol (PDO), 1,4-butanediol (1,4-BDO) and 1,3-butanediol (1,3-BDO) are appealing monomers for producing industrially important polymers and plastics. Therefore, the commercialization of bio-based diols is highly important for supporting the growth of biomanufacturing for the fiber industry. This review focuses primarily on the microbial production of PDO, 1,4-BDO and 1,3-BDO with respect to different microbial strains and biological routes. In addition, metabolic platforms which are designed to produce various diols using generic bioconversion strategies are reviewed for the first time. Finally, we also summarize and discuss recent developments in the downstream processing of PDO according to their advantages and drawbacks, which is taken as an example to present the prospects and challenges for industrial separation and purification of diols from microbial fermentation broth.

中文翻译：

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二醇生物合成及下游加工研究进展


二醇是重要的平台化学品，在化工医药、食品、饲料和化妆品等领域有着广泛的应用。特别是，1,3-丙二醇 (PDO)、1,4-丁二醇 (1,4-BDO) 和 1,3-丁二醇 (1,3-BDO) 是生产工业上重要的聚合物和塑料的有吸引力的单体。因此，生物基二醇的商业化对于支持纤维行业生物制造的增长非常重要。本综述主要关注不同微生物菌株和生物途径的 PDO、1,4-BDO 和 1,3-BDO 的微生物生产。此外，首次审查了旨在使用通用生物转化策略生产各种二醇的代谢平台。最后，我们还根据其优缺点总结和讨论了PDO下游加工的最新进展，并以此为例介绍了从微生物发酵液中工业分离纯化二醇的前景和挑战。