The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism. In this Review, we explore the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes. Major developmental events are discussed in the context of their effect on the establishment of both functional hypothalamic neuronal circuits and brain–body interfaces that are pivotal to the control of metabolism. Emerging evidence indicates that aberrations in molecular pathways during tuberal hypothalamic development contribute to metabolic dysregulation. Understanding the molecular underpinnings of tuberal hypothalamic development provides a comprehensive view of neurodevelopmental processes and offers a promising avenue for future targeted interventions to prevent and treat metabolic disorders.

结节性下丘脑调节一系列重要的生理过程，包括能量稳态和新陈代谢。在这篇综述中，我们探讨了控制结节性下丘脑发育的复杂分子机制和信号通路，重点关注塑造代谢结果的方面。主要发育事件在其对功能性下丘脑神经元回路和脑-体界面建立的影响的背景下进行讨论，而这对于新陈代谢的控制至关重要。新的证据表明，下丘脑结节发育过程中分子途径的畸变会导致代谢失调。了解结节性下丘脑发育的分子基础提供了对神经发育过程的全面了解，并为未来预防和治疗代谢性疾病的有针对性的干预措施提供了有希望的途径。