Di-2-ethylhexyl phthalate is a plasticizer of health concern due to its presence in the environment and its association with health issues such as metabolic and neurodevelopment disorders. We review the potential hazards and mechansims of di-2-ethylhexyl phthalate exposure on the metabolism and neurodevelopment. Di-2-ethylhexyl phthalate is closely linked to metabolic diseases such as obesity and diabetes, interfering with adipocyte differentiation and lipid metabolism through multiple pathways, thereby disrupting the energy balance. Di-2-ethylhexyl phthalate is also altering the pancreatic function and glucose metabolism. In terms of neurodevelopment, exposure to di-2-ethylhexyl phthalate is associated with neurological abnormalities, crossing the blood–brain barrier and directly impacting the central nervous system. Early exposure may lead to abnormalities in neuronal migration, synapse formation, and neural connectivity, potentially resulting in cognitive and behavioral consequences. Di-2-ethylhexyl phthalate exposure, particularly during childhood and adolescence, may have long-term effects on learning, memory, and behavior.

邻苯二甲酸二-2-乙基己酯是一种引起健康关注的增塑剂，因为它存在于环境中，并且与代谢和神经发育障碍等健康问题有关。我们回顾了邻苯二甲酸二-2-乙基己酯暴露对代谢和神经发育的潜在危害和机制。邻苯二甲酸二-2-乙基己酯与肥胖、糖尿病等代谢性疾病密切相关，通过多种途径干扰脂肪细胞分化和脂质代谢，从而破坏能量平衡。邻苯二甲酸二-2-乙基己酯还会改变胰腺功能和葡萄糖代谢。在神经发育方面，接触邻苯二甲酸二-2-乙基己酯与神经系统异常有关，它会穿过血脑屏障并直接影响中枢神经系统。早期接触可能会导致神经元迁移、突触形成和神经连接异常，从而可能导致认知和行为后果。接触邻苯二甲酸二-2-乙基己酯，尤其是在儿童期和青春期，可能对学习、记忆和行为产生长期影响。